Mechanisms of carnosine-induced activation of neuronal cells

Shuntaro Yamashita, Mikako Sato, Takashi Matsumoto, Keishi Kadooka, Takanori Hasegawa, Tatsuya Fujimura, Yoshinori Katakura

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Carnosine (β-Ala-l-His), an imidazole dipeptide, is known to have many functions. Recently, we demonstrated in a double-blind randomized controlled trial that carnosine is capable of preserving cognitive function in elderly people. In the current study, we assessed the ability of carnosine to activate the brain, and we tried to clarify the molecular mechanisms behind this activation. Our results demonstrate that carnosine permeates the blood brain barrier and activates glial cells within the brain, causing them to secrete neurotrophins, including BDNF and NGF. These results point to a novel mechanism of carnosine-induced neuronal activation. Our results suggest that carnosine should be recognized as a functional food factor that helps achieve anti-brain aging.

Original languageEnglish
Pages (from-to)683-688
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume82
Issue number4
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Carnosine
Chemical activation
Brain
Functional Food
Aptitude
Dipeptides
Brain-Derived Neurotrophic Factor
Nerve Growth Factors
Nerve Growth Factor
Blood-Brain Barrier
Neuroglia
Cognition
Randomized Controlled Trials
Aging of materials

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Mechanisms of carnosine-induced activation of neuronal cells. / Yamashita, Shuntaro; Sato, Mikako; Matsumoto, Takashi; Kadooka, Keishi; Hasegawa, Takanori; Fujimura, Tatsuya; Katakura, Yoshinori.

In: Bioscience, Biotechnology and Biochemistry, Vol. 82, No. 4, 01.01.2018, p. 683-688.

Research output: Contribution to journalArticle

Yamashita, S, Sato, M, Matsumoto, T, Kadooka, K, Hasegawa, T, Fujimura, T & Katakura, Y 2018, 'Mechanisms of carnosine-induced activation of neuronal cells', Bioscience, Biotechnology and Biochemistry, vol. 82, no. 4, pp. 683-688. https://doi.org/10.1080/09168451.2017.1413325
Yamashita S, Sato M, Matsumoto T, Kadooka K, Hasegawa T, Fujimura T et al. Mechanisms of carnosine-induced activation of neuronal cells. Bioscience, Biotechnology and Biochemistry. 2018 Jan 1;82(4):683-688. https://doi.org/10.1080/09168451.2017.1413325
Yamashita, Shuntaro ; Sato, Mikako ; Matsumoto, Takashi ; Kadooka, Keishi ; Hasegawa, Takanori ; Fujimura, Tatsuya ; Katakura, Yoshinori. / Mechanisms of carnosine-induced activation of neuronal cells. In: Bioscience, Biotechnology and Biochemistry. 2018 ; Vol. 82, No. 4. pp. 683-688.
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