Mechanisms of neural stem cell fate determination: extracellular cues and intracellular programs.

Masahiko Abematsu, Ian Smith, Kinichi Nakashima

Research output: Contribution to journalReview article

23 Citations (Scopus)


Multipotent neural stem cells (NSC) possess the ability to self-renew and to generate the three major central nervous system (CNS) cell types: neurons, astrocytes and oligodendrocytes. However, the molecular mechanisms that control NSC fate specification are not yet fully understood. Recent studies have provided evidence that soluble protein mediators such as cytokines and transcriptional factors play critical roles in cell fate determination. Furthermore, it has become apparent that epigenetic gene regulation plays an important intracellular role as cell-intrinsic programs in the specification of cell lineages. In this review, we focus on recent progress that addresses the mechanisms of NSC fate specification and their possible contribution in the field of regenerative medicine.

Original languageEnglish
Pages (from-to)267-277
Number of pages11
JournalCurrent stem cell research & therapy
Issue number2
Publication statusPublished - Jan 1 2006
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)

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