Mechanistic analogy between metal ion-catalyzed self-splicing of protein and RNA.

Tohru Takarada, A. Yamamura, M. Yashiro, M. Komiyama

Research output: Contribution to journalArticle

2 Citations (Scopus)


Recent studies have shown that RNA hydrolysis is remarkably promoted by metal ions and suitably designed metal complexes. We have found that autocleavage of dipeptides X-Ser and a tripeptide Gly-Ser-Ala is catalyzed by Zn(II) at 70 degrees C and pH 7.0. A mechanistic analogy between metal ion-catalyzed hydrolysis of peptides and RNA is suggested.

Original languageEnglish
Pages (from-to)245-246
Number of pages2
JournalNucleic acids symposium series
Issue number37
Publication statusPublished - Jan 1 1997
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Medicine(all)

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