Recent studies have shown that RNA hydrolysis is remarkably promoted by metal ions and suitably designed metal complexes. We have found that autocleavage of dipeptides X-Ser and a tripeptide Gly-Ser-Ala is catalyzed by Zn(II) at 70 degrees C and pH 7.0. A mechanistic analogy between metal ion-catalyzed hydrolysis of peptides and RNA is suggested.
|Number of pages||2|
|Journal||Nucleic acids symposium series|
|Publication status||Published - Jan 1 1997|
All Science Journal Classification (ASJC) codes