Mechanistic insights into mutually exclusive splicing in dynamin 1

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Summary: Mutually exclusive splicing is a strictly regulated pattern of alternative splicing. A specific group of mutually exclusive splicing events has been shown to be regulated by the formation of specific RNA secondary structures. This type of regulation has been shown to exist only in arthropods. The present study involved a detailed sequence analysis of human gene structures that undergo mutually exclusive splicing, which showed that this type of regulation may also occur in dynamin 1 in mammals. A phylogenetic analysis revealed that the dynamin 1 orthologs in invertebrates did not share the same sequence features, which suggests that the regulatory mechanism has independently evolved in the mammalian lineage. Therefore, the emergence of this elaborate mechanism for mutually exclusive splicing may be attributable to mechanistic convergence. Supplementary information: Supplementary data are available at Bioinformatics online.

    Original languageEnglish
    Pages (from-to)2084-2087
    Number of pages4
    JournalBioinformatics
    Volume29
    Issue number17
    DOIs
    Publication statusPublished - Sep 1 2013

    Fingerprint

    Dynamin I
    Mutually exclusive
    Mammals
    Bioinformatics
    RNA
    Genes
    Arthropods
    Alternative Splicing
    Invertebrates
    Computational Biology
    Sequence Analysis
    Phylogenetic Analysis
    RNA Secondary Structure
    Strictly
    Gene

    All Science Journal Classification (ASJC) codes

    • Statistics and Probability
    • Biochemistry
    • Molecular Biology
    • Computer Science Applications
    • Computational Theory and Mathematics
    • Computational Mathematics

    Cite this

    Mechanistic insights into mutually exclusive splicing in dynamin 1. / Suyama, Mikita.

    In: Bioinformatics, Vol. 29, No. 17, 01.09.2013, p. 2084-2087.

    Research output: Contribution to journalArticle

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