Mechano-active scaffold design of small-diameter artificial graft made of electrospun segmented polyurethane fabrics

Takehisa Matsuda, Maki Ihara, Hiroyuki Inoguchi, Il Keun Kwon, Keiichi Takamizawa, Satoru Kidoaki

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)

Abstract

To fabricate a "mechano-active" tubular scaffold of nonwoven mesh-type small-diameter artificial graft made of the synthetic durable elastomer, segmented polyurethane, the fabrication technique of electrospinning on a mandrel under a high rotation speed and transverse movement was used. Emphasis was placed on how the rotation speed of the mandrel and the fusion or welding states of fibers at contact points affect the compliance (ease of intraluminal pressure-dependent circumferential inflation) and Young's modulus determined by uniaxial stretching in the longitudinal and circumferential directions. The results showed that a high rotation speed is attributed to exhibit isotropic mechanical properties in the entire range of applied strain but reduces the compliance, and a high fusion state, which is produced using a mixed solvent with a high content of high-boiling-point solvent, reduces the compliance but is expected to exhibit high durability in a continuously loaded pulsatile stress field in an arterial circulatory system.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalJournal of Biomedical Materials Research - Part A
Volume73
Issue number1
DOIs
Publication statusPublished - Apr 1 2005

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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