Mechanobiological signal transduction in differentiating chondrocyte and new configuration for mechanical stress culture

Ichiro Takahashi, Taisuke Masuda, Fumihito Arai, Takahisa Anada, Toshio Fukuda, Osamu Suzuki, Teruko Takano-Yamamoto

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Musculoskeletal system regulates and supports mammalian body movement by generating force and by resisting to the force exerted on the body. Skeletal tissues, bone, cartilage, muscle and tendon are mechano-responsive tissues consisted of osteoblasts, chondrocytes, myocytes and fibroblasts and their specific extracellular matrices (ECMs). Mechanical stress presents a variety of effects on the metabolism and differentiation state of these cells. During bone growth, growth plate cartilage plays a pivotal role in growth in length of bone by providing templates consisted of cartilage specific ECM, which is replaced by bone. Chondrocytes, form cartilage in synovial joints and growth plates, respond to compressive force by activating their metabolism and progressing differentiation, while tensile stimulation inhibits their differentiation. Mechanical stimulation is translated into intracellular signaling, which regulates the differentiation state and metabolism of chondrocytes. To analyze the mechanobiological response, we have been developing mechanical stress culture device. Here, we present the mechanical stress culture device and mechnobiological response of differentiating chondrocytes to stretch stimulation

Original languageEnglish
Title of host publicationProceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
Pages1061-1064
Number of pages4
DOIs
Publication statusPublished - Aug 28 2007
Externally publishedYes
Event2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 - Bangkok, Thailand
Duration: Jan 16 2007Jan 19 2007

Publication series

NameProceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

Other

Other2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
CountryThailand
CityBangkok
Period1/16/071/19/07

All Science Journal Classification (ASJC) codes

  • Computer Networks and Communications
  • Computer Science Applications
  • Electrical and Electronic Engineering

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    Takahashi, I., Masuda, T., Arai, F., Anada, T., Fukuda, T., Suzuki, O., & Takano-Yamamoto, T. (2007). Mechanobiological signal transduction in differentiating chondrocyte and new configuration for mechanical stress culture. In Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 (pp. 1061-1064). [4160504] (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007). https://doi.org/10.1109/NEMS.2007.352201