Mechanobiology of endothelial cells related to the pathogenesis of arterial disease

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Arteriosclerosis occurs preferentially at the inner curvature of blood vessels where shear stress induced by blood flow is low. Endothelial cells, which line the inner surface of blood vessels, transport all substances from vessels to tissues. It is well known that many functions of endothelial cells are affected by fluid shear stress, and it has been hypothesized that the dysfunction of endothelial transport is related to arteriogenesis. Endothelial transport is divided into two primary types: paracellular transport, which is passive, and transcellular transport, which is active. In this chapter, we introduce these endothelial transport processes and discuss the ways they are influenced by various shear stress conditions.

Original languageEnglish
Title of host publicationVascular Engineering
Subtitle of host publicationNew Prospects of Vascular Medicine and Biology with a Multidiscipline Approach
PublisherSpringer Japan
Pages199-209
Number of pages11
ISBN (Electronic)9784431548010
ISBN (Print)9784431548003
DOIs
Publication statusPublished - Jan 1 2016

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Biophysics
Endothelial cells
Blood Vessels
Shear stress
Endothelial Cells
Blood vessels
Transcytosis
Arteriosclerosis
Cell Line
Blood
Tissue
Fluids

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)

Cite this

Kudo, S. (2016). Mechanobiology of endothelial cells related to the pathogenesis of arterial disease. In Vascular Engineering: New Prospects of Vascular Medicine and Biology with a Multidiscipline Approach (pp. 199-209). Springer Japan. https://doi.org/10.1007/978-4-431-54801-0_10

Mechanobiology of endothelial cells related to the pathogenesis of arterial disease. / Kudo, Susumu.

Vascular Engineering: New Prospects of Vascular Medicine and Biology with a Multidiscipline Approach. Springer Japan, 2016. p. 199-209.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kudo, S 2016, Mechanobiology of endothelial cells related to the pathogenesis of arterial disease. in Vascular Engineering: New Prospects of Vascular Medicine and Biology with a Multidiscipline Approach. Springer Japan, pp. 199-209. https://doi.org/10.1007/978-4-431-54801-0_10
Kudo S. Mechanobiology of endothelial cells related to the pathogenesis of arterial disease. In Vascular Engineering: New Prospects of Vascular Medicine and Biology with a Multidiscipline Approach. Springer Japan. 2016. p. 199-209 https://doi.org/10.1007/978-4-431-54801-0_10
Kudo, Susumu. / Mechanobiology of endothelial cells related to the pathogenesis of arterial disease. Vascular Engineering: New Prospects of Vascular Medicine and Biology with a Multidiscipline Approach. Springer Japan, 2016. pp. 199-209
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