Mechanobiology of endothelial cells related to the pathogenesis of arterial disease

Susumu Kudo

doi:10.1007/978-4-431-54801-0_10

Mechanobiology of endothelial cells related to the pathogenesis of arterial disease

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Arteriosclerosis occurs preferentially at the inner curvature of blood vessels where shear stress induced by blood flow is low. Endothelial cells, which line the inner surface of blood vessels, transport all substances from vessels to tissues. It is well known that many functions of endothelial cells are affected by fluid shear stress, and it has been hypothesized that the dysfunction of endothelial transport is related to arteriogenesis. Endothelial transport is divided into two primary types: paracellular transport, which is passive, and transcellular transport, which is active. In this chapter, we introduce these endothelial transport processes and discuss the ways they are influenced by various shear stress conditions.

Original language	English
Title of host publication	Vascular Engineering
Subtitle of host publication	New Prospects of Vascular Medicine and Biology with a Multidiscipline Approach
Publisher	Springer Japan
Pages	199-209
Number of pages	11
ISBN (Electronic)	9784431548010
ISBN (Print)	9784431548003
DOIs	https://doi.org/10.1007/978-4-431-54801-0_10
Publication status	Published - Jan 1 2016

All Science Journal Classification (ASJC) codes

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)
Engineering(all)

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10.1007/978-4-431-54801-0_10

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Mechanobiology of endothelial cells related to the pathogenesis of arterial disease

Abstract

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