Medication for hypercholesterolemia and the risk of nonfatal acute myocardial infarction - A case-control study in Japan

Hiroko Kodama, Suminori Kono, Ying Liu, Shizuka Sasazuki, Keitaro Tanaka, Shoji Tokunaga, Kouichi Yoshimasu, Masakazu Washio, Masahiro Mohri, Akira Takeshita, Kikuo Arakawa, Munehito Ideishi, Takanobu Nii, Kazuyuki Shirai, Koichi Handa, Keiichi Tanaka, Hidekazu Arai, Yoshitaka Doi, Tomoki Kawano, Osamu NakagakiKazuyuki Takada, Yasushi Sasaki, Yasushi Ishihara, Tetsuji Inoh, Fumio Oshima, Tomoki Honma, Samon Koyanagi, Yasuo Hayashi, Yuji Maruoka, Yuji Taira, Ken Abe, Shunji Miake, Suguru Mori, Shinya Oda, Ryuichi Nagashima, Ichiro Ohmura, Tadayuki Hiroki, Ryuichiro Miyawaki, Juzabu Jinnouchi, Shinichiro Ito, Kazuyuki Saito, Terutoshi Tanioka, Kohzo Iino, Yasuhiro Maeda, Yasuhiko Orita, Yohsuke Katsuta, Hidero Nakazono, Naotaka Hamasaki, Hitomi Hayabuchi, Sumie Jingu, Ryoko Hayashi, Masako Sakamoto, Yoshiki Egashira, Tadashi Enomoto, Masanori Fujino, Keisuke Fukuda, Masakazu Gondo, Shouhei Hata, Satoshi Hiratsuka, Takashi Ichiki, Nariaki Ikeda, Yasuto Iwanaga, Hisashi Kanaya, Yoshihiro Kato, Masaki Kohara, Nobuo Masuda, Hideyo Matsuguchi, Eiichi Murayama, Masatsugu Ohga, Hideaki Ogushi, Nobuo Ouchi, Hiroshi Saku, Teizo Sata, Kuninori Soejima, Hiroshi Takamiya, Shinsuke Takei, Masafumi Tanaka, Noritami Tashiro, Takehiko Yamada, Tsutomu Yamamoto, Masato Yoshida

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

While lowering the blood cholesterol level has been shown to decrease the risk of coronary heart disease (CHD) in Western countries, little is known about the relationship between lipid-lowering drugs and CHD risk in Japan. A case-control study of nonfatal acute myocardial infarction (AMI) was conducted in Japan. A total of 658 cases aged 40-79 years and 1,274 community controls matched to each case by sex, year of birth, and residence were compared for their use of lipid-lowering drugs and level of serum total cholesterol. The study used 2 definitions of hypercholesterolemia: (i) either serum total cholesterol ≥6.21 mmol/L (240 mg/dl) or current use of hypolipidemic drugs; and (ii) either serum total cholesterol of ≥5.69 mmol/L (220 mg/dl) or current use of hypolipidemic drugs. Unconditional logistic regression analysis was used to adjust for hypertension, angina pectoris, diabetes mellitus, smoking, alcohol use, and physical activity as well as for sex and age. As compared with nonhypercholesterolemic subjects, those with untreated hypercholesterolemia had a significantly increased risk of AMI whereas no increase in the risk was observed for treated hypercholesterolemia. In the group with hypercholesterolemia, regardless of the definition, the adjusted odds ratios decreased progressively when the achieved cholesterol levels were lower.

Original languageEnglish
Pages (from-to)463-468
Number of pages6
JournalCirculation Journal
Volume66
Issue number5
DOIs
Publication statusPublished - May 22 2002

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Kodama, H., Kono, S., Liu, Y., Sasazuki, S., Tanaka, K., Tokunaga, S., Yoshimasu, K., Washio, M., Mohri, M., Takeshita, A., Arakawa, K., Ideishi, M., Nii, T., Shirai, K., Handa, K., Tanaka, K., Arai, H., Doi, Y., Kawano, T., ... Yoshida, M. (2002). Medication for hypercholesterolemia and the risk of nonfatal acute myocardial infarction - A case-control study in Japan. Circulation Journal, 66(5), 463-468. https://doi.org/10.1253/circj.66.463