Medication for hypercholesterolemia and the risk of nonfatal acute myocardial infarction - A case-control study in Japan

Hiroko Kodama, Suminori Kono, Ying Liu, Shizuka Sasazuki, Keitaro Tanaka, Shoji Tokunaga, Kouichi Yoshimasu, Masakazu Washio, Masahiro Mohri, Akira Takeshita, Kikuo Arakawa, Munehito Ideishi, Takanobu Nii, Kazuyuki Shirai, Koichi Handa, Keiichi Tanaka, Hidekazu Arai, Yoshitaka Doi, Tomoki Kawano, Osamu Nakagaki & 61 others Kazuyuki Takada, Yasushi Sasaki, Yasushi Ishihara, Tetsuji Inoh, Fumio Oshima, Tomoki Honma, Samon Koyanagi, Yasuo Hayashi, Yuji Maruoka, Yuji Taira, Ken Abe, Shunji Miake, Suguru Mori, Shinya Oda, Ryuichi Nagashima, Ichiro Ohmura, Tadayuki Hiroki, Ryuichiro Miyawaki, Juzabu Jinnouchi, Shinichi Ito, Kazuyuki Saito, Terutoshi Tanioka, Kohzo Iino, Yasuhiro Maeda, Yasuhiko Orita, Yohsuke Katsuta, Hidero Nakazono, Naotaka Hamasaki, Hitomi Hayabuchi, Sumie Jingu, Ryoko Hayashi, Masako Sakamoto, Yoshiki Egashira, Tadashi Enomoto, Masanori Fujino, Keisuke Fukuda, Masakazu Gondo, Shouhei Hata, Satoshi Hiratsuka, Takashi Ichiki, Nariaki Ikeda, Yasuto Iwanaga, Hisashi Kanaya, Yoshihiro Kato, Masaki Kohara, Nobuo Masuda, Hideyo Matsuguchi, Eiichi Murayama, Masatsugu Ohga, Hideaki Ogushi, Nobuo Ouchi, Hiroshi Saku, Teizo Sata, Kuninori Soejima, Hiroshi Takamiya, Shinsuke Takei, Masafumi Tanaka, Noritami Tashiro, Takehiko Yamada, Tsutomu Yamamoto, Masato Yoshida

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

While lowering the blood cholesterol level has been shown to decrease the risk of coronary heart disease (CHD) in Western countries, little is known about the relationship between lipid-lowering drugs and CHD risk in Japan. A case-control study of nonfatal acute myocardial infarction (AMI) was conducted in Japan. A total of 658 cases aged 40-79 years and 1,274 community controls matched to each case by sex, year of birth, and residence were compared for their use of lipid-lowering drugs and level of serum total cholesterol. The study used 2 definitions of hypercholesterolemia: (i) either serum total cholesterol ≥6.21 mmol/L (240 mg/dl) or current use of hypolipidemic drugs; and (ii) either serum total cholesterol of ≥5.69 mmol/L (220 mg/dl) or current use of hypolipidemic drugs. Unconditional logistic regression analysis was used to adjust for hypertension, angina pectoris, diabetes mellitus, smoking, alcohol use, and physical activity as well as for sex and age. As compared with nonhypercholesterolemic subjects, those with untreated hypercholesterolemia had a significantly increased risk of AMI whereas no increase in the risk was observed for treated hypercholesterolemia. In the group with hypercholesterolemia, regardless of the definition, the adjusted odds ratios decreased progressively when the achieved cholesterol levels were lower.

Original languageEnglish
Pages (from-to)463-468
Number of pages6
JournalCirculation Journal
Volume66
Issue number5
DOIs
Publication statusPublished - May 22 2002

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Hypercholesterolemia
Case-Control Studies
Japan
Myocardial Infarction
Cholesterol
Hypolipidemic Agents
Coronary Disease
Serum
Lipids
Angina Pectoris
Pharmaceutical Preparations
Diabetes Mellitus
Logistic Models
Smoking
Odds Ratio
Regression Analysis
Alcohols
Parturition
Hypertension

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Medication for hypercholesterolemia and the risk of nonfatal acute myocardial infarction - A case-control study in Japan. / Kodama, Hiroko; Kono, Suminori; Liu, Ying; Sasazuki, Shizuka; Tanaka, Keitaro; Tokunaga, Shoji; Yoshimasu, Kouichi; Washio, Masakazu; Mohri, Masahiro; Takeshita, Akira; Arakawa, Kikuo; Ideishi, Munehito; Nii, Takanobu; Shirai, Kazuyuki; Handa, Koichi; Tanaka, Keiichi; Arai, Hidekazu; Doi, Yoshitaka; Kawano, Tomoki; Nakagaki, Osamu; Takada, Kazuyuki; Sasaki, Yasushi; Ishihara, Yasushi; Inoh, Tetsuji; Oshima, Fumio; Honma, Tomoki; Koyanagi, Samon; Hayashi, Yasuo; Maruoka, Yuji; Taira, Yuji; Abe, Ken; Miake, Shunji; Mori, Suguru; Oda, Shinya; Nagashima, Ryuichi; Ohmura, Ichiro; Hiroki, Tadayuki; Miyawaki, Ryuichiro; Jinnouchi, Juzabu; Ito, Shinichi; Saito, Kazuyuki; Tanioka, Terutoshi; Iino, Kohzo; Maeda, Yasuhiro; Orita, Yasuhiko; Katsuta, Yohsuke; Nakazono, Hidero; Hamasaki, Naotaka; Hayabuchi, Hitomi; Jingu, Sumie; Hayashi, Ryoko; Sakamoto, Masako; Egashira, Yoshiki; Enomoto, Tadashi; Fujino, Masanori; Fukuda, Keisuke; Gondo, Masakazu; Hata, Shouhei; Hiratsuka, Satoshi; Ichiki, Takashi; Ikeda, Nariaki; Iwanaga, Yasuto; Kanaya, Hisashi; Kato, Yoshihiro; Kohara, Masaki; Masuda, Nobuo; Matsuguchi, Hideyo; Murayama, Eiichi; Ohga, Masatsugu; Ogushi, Hideaki; Ouchi, Nobuo; Saku, Hiroshi; Sata, Teizo; Soejima, Kuninori; Takamiya, Hiroshi; Takei, Shinsuke; Tanaka, Masafumi; Tashiro, Noritami; Yamada, Takehiko; Yamamoto, Tsutomu; Yoshida, Masato.

In: Circulation Journal, Vol. 66, No. 5, 22.05.2002, p. 463-468.

Research output: Contribution to journalArticle

Kodama, H, Kono, S, Liu, Y, Sasazuki, S, Tanaka, K, Tokunaga, S, Yoshimasu, K, Washio, M, Mohri, M, Takeshita, A, Arakawa, K, Ideishi, M, Nii, T, Shirai, K, Handa, K, Tanaka, K, Arai, H, Doi, Y, Kawano, T, Nakagaki, O, Takada, K, Sasaki, Y, Ishihara, Y, Inoh, T, Oshima, F, Honma, T, Koyanagi, S, Hayashi, Y, Maruoka, Y, Taira, Y, Abe, K, Miake, S, Mori, S, Oda, S, Nagashima, R, Ohmura, I, Hiroki, T, Miyawaki, R, Jinnouchi, J, Ito, S, Saito, K, Tanioka, T, Iino, K, Maeda, Y, Orita, Y, Katsuta, Y, Nakazono, H, Hamasaki, N, Hayabuchi, H, Jingu, S, Hayashi, R, Sakamoto, M, Egashira, Y, Enomoto, T, Fujino, M, Fukuda, K, Gondo, M, Hata, S, Hiratsuka, S, Ichiki, T, Ikeda, N, Iwanaga, Y, Kanaya, H, Kato, Y, Kohara, M, Masuda, N, Matsuguchi, H, Murayama, E, Ohga, M, Ogushi, H, Ouchi, N, Saku, H, Sata, T, Soejima, K, Takamiya, H, Takei, S, Tanaka, M, Tashiro, N, Yamada, T, Yamamoto, T & Yoshida, M 2002, 'Medication for hypercholesterolemia and the risk of nonfatal acute myocardial infarction - A case-control study in Japan', Circulation Journal, vol. 66, no. 5, pp. 463-468. https://doi.org/10.1253/circj.66.463
Kodama, Hiroko ; Kono, Suminori ; Liu, Ying ; Sasazuki, Shizuka ; Tanaka, Keitaro ; Tokunaga, Shoji ; Yoshimasu, Kouichi ; Washio, Masakazu ; Mohri, Masahiro ; Takeshita, Akira ; Arakawa, Kikuo ; Ideishi, Munehito ; Nii, Takanobu ; Shirai, Kazuyuki ; Handa, Koichi ; Tanaka, Keiichi ; Arai, Hidekazu ; Doi, Yoshitaka ; Kawano, Tomoki ; Nakagaki, Osamu ; Takada, Kazuyuki ; Sasaki, Yasushi ; Ishihara, Yasushi ; Inoh, Tetsuji ; Oshima, Fumio ; Honma, Tomoki ; Koyanagi, Samon ; Hayashi, Yasuo ; Maruoka, Yuji ; Taira, Yuji ; Abe, Ken ; Miake, Shunji ; Mori, Suguru ; Oda, Shinya ; Nagashima, Ryuichi ; Ohmura, Ichiro ; Hiroki, Tadayuki ; Miyawaki, Ryuichiro ; Jinnouchi, Juzabu ; Ito, Shinichi ; Saito, Kazuyuki ; Tanioka, Terutoshi ; Iino, Kohzo ; Maeda, Yasuhiro ; Orita, Yasuhiko ; Katsuta, Yohsuke ; Nakazono, Hidero ; Hamasaki, Naotaka ; Hayabuchi, Hitomi ; Jingu, Sumie ; Hayashi, Ryoko ; Sakamoto, Masako ; Egashira, Yoshiki ; Enomoto, Tadashi ; Fujino, Masanori ; Fukuda, Keisuke ; Gondo, Masakazu ; Hata, Shouhei ; Hiratsuka, Satoshi ; Ichiki, Takashi ; Ikeda, Nariaki ; Iwanaga, Yasuto ; Kanaya, Hisashi ; Kato, Yoshihiro ; Kohara, Masaki ; Masuda, Nobuo ; Matsuguchi, Hideyo ; Murayama, Eiichi ; Ohga, Masatsugu ; Ogushi, Hideaki ; Ouchi, Nobuo ; Saku, Hiroshi ; Sata, Teizo ; Soejima, Kuninori ; Takamiya, Hiroshi ; Takei, Shinsuke ; Tanaka, Masafumi ; Tashiro, Noritami ; Yamada, Takehiko ; Yamamoto, Tsutomu ; Yoshida, Masato. / Medication for hypercholesterolemia and the risk of nonfatal acute myocardial infarction - A case-control study in Japan. In: Circulation Journal. 2002 ; Vol. 66, No. 5. pp. 463-468.
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AU - Kodama, Hiroko

AU - Kono, Suminori

AU - Liu, Ying

AU - Sasazuki, Shizuka

AU - Tanaka, Keitaro

AU - Tokunaga, Shoji

AU - Yoshimasu, Kouichi

AU - Washio, Masakazu

AU - Mohri, Masahiro

AU - Takeshita, Akira

AU - Arakawa, Kikuo

AU - Ideishi, Munehito

AU - Nii, Takanobu

AU - Shirai, Kazuyuki

AU - Handa, Koichi

AU - Tanaka, Keiichi

AU - Arai, Hidekazu

AU - Doi, Yoshitaka

AU - Kawano, Tomoki

AU - Nakagaki, Osamu

AU - Takada, Kazuyuki

AU - Sasaki, Yasushi

AU - Ishihara, Yasushi

AU - Inoh, Tetsuji

AU - Oshima, Fumio

AU - Honma, Tomoki

AU - Koyanagi, Samon

AU - Hayashi, Yasuo

AU - Maruoka, Yuji

AU - Taira, Yuji

AU - Abe, Ken

AU - Miake, Shunji

AU - Mori, Suguru

AU - Oda, Shinya

AU - Nagashima, Ryuichi

AU - Ohmura, Ichiro

AU - Hiroki, Tadayuki

AU - Miyawaki, Ryuichiro

AU - Jinnouchi, Juzabu

AU - Ito, Shinichi

AU - Saito, Kazuyuki

AU - Tanioka, Terutoshi

AU - Iino, Kohzo

AU - Maeda, Yasuhiro

AU - Orita, Yasuhiko

AU - Katsuta, Yohsuke

AU - Nakazono, Hidero

AU - Hamasaki, Naotaka

AU - Hayabuchi, Hitomi

AU - Jingu, Sumie

AU - Hayashi, Ryoko

AU - Sakamoto, Masako

AU - Egashira, Yoshiki

AU - Enomoto, Tadashi

AU - Fujino, Masanori

AU - Fukuda, Keisuke

AU - Gondo, Masakazu

AU - Hata, Shouhei

AU - Hiratsuka, Satoshi

AU - Ichiki, Takashi

AU - Ikeda, Nariaki

AU - Iwanaga, Yasuto

AU - Kanaya, Hisashi

AU - Kato, Yoshihiro

AU - Kohara, Masaki

AU - Masuda, Nobuo

AU - Matsuguchi, Hideyo

AU - Murayama, Eiichi

AU - Ohga, Masatsugu

AU - Ogushi, Hideaki

AU - Ouchi, Nobuo

AU - Saku, Hiroshi

AU - Sata, Teizo

AU - Soejima, Kuninori

AU - Takamiya, Hiroshi

AU - Takei, Shinsuke

AU - Tanaka, Masafumi

AU - Tashiro, Noritami

AU - Yamada, Takehiko

AU - Yamamoto, Tsutomu

AU - Yoshida, Masato

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