Melanin Biosynthesis Inhibitory and Antioxidant Activities of Quercetin-3′-0-jff-D-glucoside Isolated from Allium cepa

Enos Tangke Arung, Kuniyoshi Shimizu, Ryuichiro Kondo, Shoko Furuta, Hiroya Ishikawa, Hiroyuki Tanaka

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

In the course of searching for new whitening agents, we have found that the methanol extract of dried skin of Allium cepa shows potent melanin biosynthesis inhibitory activity in B16 melanoma cells. Bioassay-guided fractionation led to the isolation of quercetin-3′-0-8- D-glucoside (1) from the methanol extract of dried skin of A. cepa, which inhibited melanin formation in B16 melanoma cells with an IC50value of 38.8 im and mushroom tyrosinase with an IC50value of 6.5 jiM using L-tyrosine and 48.5 im using L-dihydroxyphenylalanine as substrates, respectively. In addition, the antioxidant activity of 1 was evaluated in the oxygen radical absorbance capacity assay; it showed 3.04 imol Trolox equivalents/mmol. 1 was shown to be a promising ingredient that could be useful for treating hyperpigmentation and for protecting against oxidative stress.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalZeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume66
Issue number5-6
DOIs
Publication statusPublished - Jun 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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