Melanogenesis inhibitors from Coix lacryma-jobi seeds in B16-F10 melanoma cells

Yhiya Amen, Enos Tangke Arung, Mohamed S. Afifi, Ahmed F. Halim, Ahmed Ashour, Ryoji Fujimoto, Takahiro Goto, Kuniyoshi Shimizu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

An adenine derivative, 9-β-D-glucopyranosyl adenine, reported for the first time from a natural source, in addition to nine known compounds were isolated from the seeds of Coix lacryma-jobi. Their structures were elucidated based on extensive spectroscopic and chemical studies. The isolated compounds and the ethanol extract have been assayed for melanin inhibition using B16-F10 melanoma cell line. The results of our study suggested the potential use of Coix lacryma-jobi seeds as a skin whitening agent and reveal the seeds to be a rich source of important phytochemicals with melanogenesis inhibitory activity. Among the isolated compounds, coixol (2) and 2-O-β-glucopyranosyl-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (8) exhibited potent melanogenesis inhibitory activity with no obvious melanocytotoxicity. The rest of the compounds showed weak to moderate activity.

Original languageEnglish
Pages (from-to)2712-2718
Number of pages7
JournalNatural Product Research
Volume31
Issue number23
DOIs
Publication statusPublished - Dec 2 2017

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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  • Cite this

    Amen, Y., Arung, E. T., Afifi, M. S., Halim, A. F., Ashour, A., Fujimoto, R., Goto, T., & Shimizu, K. (2017). Melanogenesis inhibitors from Coix lacryma-jobi seeds in B16-F10 melanoma cells. Natural Product Research, 31(23), 2712-2718. https://doi.org/10.1080/14786419.2017.1292270