Melanoma and Immune Checkpoint Inhibitors

Masutaka Furue, Takamichi Ito, Naoko Wada, Maiko Wada, Takafumi Kadono, Hiroshi Uchi

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Purpose of Review: Prognosis of patients with advanced melanoma is dismal with a median overall survival of about 8 months and 5-year overall survival from a diagnosis of metastatic disease of roughly 10%. However, immune checkpoint inhibitors have brought indispensable benefits to melanoma patients. Here we will review the recent clinical efficacy and adverse events of immune checkpoint inhibitors for melanoma patients. Recent Findings: The immune checkpoint inhibitors increase confirmed objective response and prolong progression-free and overall survival of the afflicted patients in association with maintaining their quality of life. Although diverse immune-related adverse events occur, most of them are manageable by appropriate immunomodulating agents. Clinical efficacy of immune checkpoint inhibitors continues even after discontinuation of drugs. Summary: Compared with conventional therapeutic options, the immune checkpoint inhibitors appear to prolong the survival of patients with advanced melanoma. Further clinical trials are warranted to determine whether their combinatory use with other treatment options may augment benefits or not.

Original languageEnglish
Article number29
JournalCurrent Oncology Reports
Volume20
Issue number3
DOIs
Publication statusPublished - Mar 1 2018

All Science Journal Classification (ASJC) codes

  • Oncology

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