Melatonin stimulates the release of gonadotropin-inhibitory hormone by the avian hypothalamus

Vishwajit Surchowdhury, Kazutoshi Yamamoto, Takayoshi Ubuka, George E. Bentley, Atsuhiko Hattori, Kazuyoshi Tsutsui

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Gonadotropin-inhibitory hormone (GnIH), a neuropeptide that inhibits gonadotropin synthesis and release, was first identified in quail hypothalamus. GnIH acts on the pituitary and GnRH neurons in the hypothalamus via GnIH receptor to inhibit gonadal development and maintenance. In addition, GnIH neurons express melatonin receptor and melatonin induces GnIH expression in the quail brain. Thus, it seems that melatonin is a key factor controlling GnIH neural function. In the present study, we investigated the role of melatonin in the regulation of GnIH release and the correlation of GnIH release with LH release in quail. Melatonin administration dose-dependently increased GnIH release from hypothalamic explants in vitro. GnIH release was photoperiodically controlled. A clear diurnal change in GnIH release was observed in quail, and this change was negatively correlated with changes in plasma LH concentrations. GnIH release during the dark period was greater than that during the light period in explants from quail exposed to long-day photoperiods. Conversely, plasma LH concentrations decreased during the dark period. In contrast to LD, GnIH release increased under short-day photoperiods, when the duration of nocturnal secretion of melatonin increases. These results indicate that melatonin may play a role in stimulating not only GnIH expression but also GnIH release, thus inhibiting plasma LH concentrations in quail. This is the first report describing the effect of melatonin on neuropeptide release.

Original languageEnglish
Pages (from-to)271-280
Number of pages10
JournalEndocrinology
Volume151
Issue number1
DOIs
Publication statusPublished - Jan 1 2010
Externally publishedYes

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Melatonin
Gonadotropins
Hypothalamus
Hormones
Quail
Photoperiod
Neuropeptides
Melatonin Receptors
Hypothalamic Hormones
Neurons
Gonadotropin-Releasing Hormone

All Science Journal Classification (ASJC) codes

  • Endocrinology

Cite this

Melatonin stimulates the release of gonadotropin-inhibitory hormone by the avian hypothalamus. / Surchowdhury, Vishwajit; Yamamoto, Kazutoshi; Ubuka, Takayoshi; Bentley, George E.; Hattori, Atsuhiko; Tsutsui, Kazuyoshi.

In: Endocrinology, Vol. 151, No. 1, 01.01.2010, p. 271-280.

Research output: Contribution to journalArticle

Surchowdhury, Vishwajit ; Yamamoto, Kazutoshi ; Ubuka, Takayoshi ; Bentley, George E. ; Hattori, Atsuhiko ; Tsutsui, Kazuyoshi. / Melatonin stimulates the release of gonadotropin-inhibitory hormone by the avian hypothalamus. In: Endocrinology. 2010 ; Vol. 151, No. 1. pp. 271-280.
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