Memory-type CD8+ T cells protect IL-2 receptor α-deficient mice from systemic infection with herpes simplex virus type 2

H. Tsunobuchi, H. Nishimura, F. Goshima, T. Daikoku, Y. Nishiyama, Y. Yoshikai

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    IL-2Rα-deficient (IL-2Rα(-/-)) mice exhibit an impaired activation-induced cell death for T cells and develop abnormal T cell activation with age. In our study, we found that IL-2Rα(-/-) mice at the age of 5 wk contained an increased number of CD44+CD69-CD8+ T cells in lymph nodes, which expressed a high intensity of IL-2Rβ and vigorously proliferated in response to a high dose of IL-15 or IL-2. The T cells produced a large amount of IFN-γ in response to IL-15 plus IL-12 in a TCR-independent bystander manner. When IL-2Rα(-/-) mice were inoculated i.p. with HSV type 2 (HSV-2) 186 strain, they showed resistance to the infection accompanied by an increased level of serum IL-I5. The depletion of CD8+ T cells by in vivo administration of anti-CD8 mAb rendered IL-2Rα(-/-) mice susceptible to HSV-2-induced lethality. These results suggest that memory-type CD8+ T cells play a novel role in the protection against HSV-2 infection in IL-2Rα(-/-) mice.

    Original languageEnglish
    Pages (from-to)4552-4560
    Number of pages9
    JournalJournal of Immunology
    Volume165
    Issue number8
    DOIs
    Publication statusPublished - Oct 15 2000

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

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