Merkel cell carcinoma: An update and immunotherapy

Hiroshi Uchi

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer with frequent metastasis and death. MCC has a mortality rate of 30%, making it more lethal than malignant melanoma, and incidence of MCC has increased almost fourfold over the past 20 years in the USA. MCC has long been considered to be an immunogenic cancer because it occurs more frequently in immunosuppressed patients from organ transplant and HIV infection than in those with immunocompetent. Chronic UV light exposure and clonal integration of Merkel cell polyomavirus (MCPyV) are two major causative factors of MCC. Approximately 80% of MCC are associated with MCPyV, and T cells specific for MCPyV oncoproteins are present in the blood and tumors of patients. Several studies have shown that a subset of MCCs express PD-1 on tumor-infiltrating lymphocytes and express PD-L1 on tumor cells, which suggests an endogenous tumor-reactive immune response that might be unleashed by anti-PD-1 or anti-PD-L1 drugs.

Original languageEnglish
Article number48
JournalFrontiers in Oncology
Volume8
Issue numberMAR
DOIs
Publication statusPublished - Mar 6 2018

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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