Mesodermal and Hematopoietic Differentiation from ES and iPS Cells

Tomoko Inoue-Yokoo, Kenzaburo Tani, Daisuke Sugiyama

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    Embryonic stem (ES) and induced pluripotent stem (iPS) cells can differentiate into any type of tissue when grown in a suitable culture environment and are considered valuable tools for regenerative medicine. In the field of hematology, generation of hematopoietic stem cells (HSCs) and mature hematopoietic cells (HCs) from ES and iPS cells through mesodermal cells, the ancestors of HCs, can facilitate transplantation and transfusion therapy. Several studies report generation of functional HCs from both mouse and human ES and iPS cells. This approach will likely be applied to individual patient-derived iPS cells for regenerative medicine approaches and drug screening in the future. Here, we summarize current studies of HC-generation from ES and iPS cells.

    Original languageEnglish
    Pages (from-to)422-434
    Number of pages13
    JournalStem Cell Reviews and Reports
    Volume9
    Issue number4
    DOIs
    Publication statusPublished - Aug 2013

    All Science Journal Classification (ASJC) codes

    • Cell Biology
    • Cancer Research

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