Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

Norihiro Kato, Fumihiko Takeuchi, Yasuharu Tabara, Tanika N. Kelly, Min Jin Go, Xueling Sim, Wan Ting Tay, Chien Hsiun Chen, Yi Zhang, Ken Yamamoto, Tomohiro Katsuya, Mitsuhiro Yokota, Young Jin Kim, Rick Twee Hee Ong, Toru Nabika, Dongfeng Gu, Li Ching Chang, Yoshihiro Kokubo, Wei Huang, Keizo OhnakaYukio Yamori, Eitaro Nakashima, Cashell E. Jaquish, Jong Young Lee, Mark Seielstad, Masato Isono, James E. Hixson, Yuan Tsong Chen, Tetsuro Miki, Xueya Zhou, Takao Sugiyama, Jae Pil Jeon, Jian Jun Liu, Ryoichi Takayanagi, Sung Soo Kim, Tin Aung, Yun Ju Sung, Xuegong Zhang, Tien Yin Wong, Bok Ghee Han, Shotai Kobayashi, Toshio Ogihara, Dingliang Zhu, Naoharu Iwai, Jer Yuarn Wu, Yik Ying Teo, E. Shyong Tai, Yoon Shin Cho, Jiang He

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Abstract

We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed up with de novo genotyping (n = 10,518) and further replication (n = 20,247) in east Asian samples. We identified genome-wide significant (P < 5 × 10-8) associations with SBP or DBP, which included variants at four new loci (ST7L-CAPZA1, FIGN-GRB14, ENPEP and NPR3) and a newly discovered variant near TBX3. Among the five newly discovered variants, we obtained significant replication in the independent samples for all of these loci except NPR3. We also confirmed seven loci previously identified in populations of European descent. Moreover, at 12q24.13 near ALDH2, we observed strong association signals (P = 7.9 × 10 -31 and P = 1.3 × 10-35 for SBP and DBP, respectively) with ethnic specificity. These findings provide new insights into blood pressure regulation and potential targets for intervention.

Original languageEnglish
Pages (from-to)531-538
Number of pages8
JournalNature genetics
Volume43
Issue number6
DOIs
Publication statusPublished - Jun 1 2011

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Genome-Wide Association Study
Meta-Analysis
Blood Pressure
Genome
Population

All Science Journal Classification (ASJC) codes

  • Genetics

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Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. / Kato, Norihiro; Takeuchi, Fumihiko; Tabara, Yasuharu; Kelly, Tanika N.; Go, Min Jin; Sim, Xueling; Tay, Wan Ting; Chen, Chien Hsiun; Zhang, Yi; Yamamoto, Ken; Katsuya, Tomohiro; Yokota, Mitsuhiro; Kim, Young Jin; Ong, Rick Twee Hee; Nabika, Toru; Gu, Dongfeng; Chang, Li Ching; Kokubo, Yoshihiro; Huang, Wei; Ohnaka, Keizo; Yamori, Yukio; Nakashima, Eitaro; Jaquish, Cashell E.; Lee, Jong Young; Seielstad, Mark; Isono, Masato; Hixson, James E.; Chen, Yuan Tsong; Miki, Tetsuro; Zhou, Xueya; Sugiyama, Takao; Jeon, Jae Pil; Liu, Jian Jun; Takayanagi, Ryoichi; Kim, Sung Soo; Aung, Tin; Sung, Yun Ju; Zhang, Xuegong; Wong, Tien Yin; Han, Bok Ghee; Kobayashi, Shotai; Ogihara, Toshio; Zhu, Dingliang; Iwai, Naoharu; Wu, Jer Yuarn; Teo, Yik Ying; Tai, E. Shyong; Cho, Yoon Shin; He, Jiang.

In: Nature genetics, Vol. 43, No. 6, 01.06.2011, p. 531-538.

Research output: Contribution to journalArticle

Kato, N, Takeuchi, F, Tabara, Y, Kelly, TN, Go, MJ, Sim, X, Tay, WT, Chen, CH, Zhang, Y, Yamamoto, K, Katsuya, T, Yokota, M, Kim, YJ, Ong, RTH, Nabika, T, Gu, D, Chang, LC, Kokubo, Y, Huang, W, Ohnaka, K, Yamori, Y, Nakashima, E, Jaquish, CE, Lee, JY, Seielstad, M, Isono, M, Hixson, JE, Chen, YT, Miki, T, Zhou, X, Sugiyama, T, Jeon, JP, Liu, JJ, Takayanagi, R, Kim, SS, Aung, T, Sung, YJ, Zhang, X, Wong, TY, Han, BG, Kobayashi, S, Ogihara, T, Zhu, D, Iwai, N, Wu, JY, Teo, YY, Tai, ES, Cho, YS & He, J 2011, 'Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians', Nature genetics, vol. 43, no. 6, pp. 531-538. https://doi.org/10.1038/ng.834
Kato, Norihiro ; Takeuchi, Fumihiko ; Tabara, Yasuharu ; Kelly, Tanika N. ; Go, Min Jin ; Sim, Xueling ; Tay, Wan Ting ; Chen, Chien Hsiun ; Zhang, Yi ; Yamamoto, Ken ; Katsuya, Tomohiro ; Yokota, Mitsuhiro ; Kim, Young Jin ; Ong, Rick Twee Hee ; Nabika, Toru ; Gu, Dongfeng ; Chang, Li Ching ; Kokubo, Yoshihiro ; Huang, Wei ; Ohnaka, Keizo ; Yamori, Yukio ; Nakashima, Eitaro ; Jaquish, Cashell E. ; Lee, Jong Young ; Seielstad, Mark ; Isono, Masato ; Hixson, James E. ; Chen, Yuan Tsong ; Miki, Tetsuro ; Zhou, Xueya ; Sugiyama, Takao ; Jeon, Jae Pil ; Liu, Jian Jun ; Takayanagi, Ryoichi ; Kim, Sung Soo ; Aung, Tin ; Sung, Yun Ju ; Zhang, Xuegong ; Wong, Tien Yin ; Han, Bok Ghee ; Kobayashi, Shotai ; Ogihara, Toshio ; Zhu, Dingliang ; Iwai, Naoharu ; Wu, Jer Yuarn ; Teo, Yik Ying ; Tai, E. Shyong ; Cho, Yoon Shin ; He, Jiang. / Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. In: Nature genetics. 2011 ; Vol. 43, No. 6. pp. 531-538.
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AU - Takeuchi, Fumihiko

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AU - Kelly, Tanika N.

AU - Go, Min Jin

AU - Sim, Xueling

AU - Tay, Wan Ting

AU - Chen, Chien Hsiun

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AU - Ohnaka, Keizo

AU - Yamori, Yukio

AU - Nakashima, Eitaro

AU - Jaquish, Cashell E.

AU - Lee, Jong Young

AU - Seielstad, Mark

AU - Isono, Masato

AU - Hixson, James E.

AU - Chen, Yuan Tsong

AU - Miki, Tetsuro

AU - Zhou, Xueya

AU - Sugiyama, Takao

AU - Jeon, Jae Pil

AU - Liu, Jian Jun

AU - Takayanagi, Ryoichi

AU - Kim, Sung Soo

AU - Aung, Tin

AU - Sung, Yun Ju

AU - Zhang, Xuegong

AU - Wong, Tien Yin

AU - Han, Bok Ghee

AU - Kobayashi, Shotai

AU - Ogihara, Toshio

AU - Zhu, Dingliang

AU - Iwai, Naoharu

AU - Wu, Jer Yuarn

AU - Teo, Yik Ying

AU - Tai, E. Shyong

AU - Cho, Yoon Shin

AU - He, Jiang

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