Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

Norihiro Kato, Fumihiko Takeuchi, Yasuharu Tabara, Tanika N. Kelly, Min Jin Go, Xueling Sim, Wan Ting Tay, Chien Hsiun Chen, Yi Zhang, Ken Yamamoto, Tomohiro Katsuya, Mitsuhiro Yokota, Young Jin Kim, Rick Twee Hee Ong, Toru Nabika, Dongfeng Gu, Li Ching Chang, Yoshihiro Kokubo, Wei Huang, Keizo OhnakaYukio Yamori, Eitaro Nakashima, Cashell E. Jaquish, Jong Young Lee, Mark Seielstad, Masato Isono, James E. Hixson, Yuan Tsong Chen, Tetsuro Miki, Xueya Zhou, Takao Sugiyama, Jae Pil Jeon, Jian Jun Liu, Ryoichi Takayanagi, Sung Soo Kim, Tin Aung, Yun Ju Sung, Xuegong Zhang, Tien Yin Wong, Bok Ghee Han, Shotai Kobayashi, Toshio Ogihara, Dingliang Zhu, Naoharu Iwai, Jer Yuarn Wu, Yik Ying Teo, E. Shyong Tai, Yoon Shin Cho, Jiang He

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Abstract

We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed up with de novo genotyping (n = 10,518) and further replication (n = 20,247) in east Asian samples. We identified genome-wide significant (P < 5 × 10-8) associations with SBP or DBP, which included variants at four new loci (ST7L-CAPZA1, FIGN-GRB14, ENPEP and NPR3) and a newly discovered variant near TBX3. Among the five newly discovered variants, we obtained significant replication in the independent samples for all of these loci except NPR3. We also confirmed seven loci previously identified in populations of European descent. Moreover, at 12q24.13 near ALDH2, we observed strong association signals (P = 7.9 × 10 -31 and P = 1.3 × 10-35 for SBP and DBP, respectively) with ethnic specificity. These findings provide new insights into blood pressure regulation and potential targets for intervention.

Original languageEnglish
Pages (from-to)531-538
Number of pages8
JournalNature genetics
Volume43
Issue number6
DOIs
Publication statusPublished - Jun 1 2011

All Science Journal Classification (ASJC) codes

  • Genetics

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    Kato, N., Takeuchi, F., Tabara, Y., Kelly, T. N., Go, M. J., Sim, X., Tay, W. T., Chen, C. H., Zhang, Y., Yamamoto, K., Katsuya, T., Yokota, M., Kim, Y. J., Ong, R. T. H., Nabika, T., Gu, D., Chang, L. C., Kokubo, Y., Huang, W., ... He, J. (2011). Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nature genetics, 43(6), 531-538. https://doi.org/10.1038/ng.834