Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: A HuGE-GSEC review

Michele L. Cote, Wei Chen, Daryn W. Smith, Simone Benhamou, Christine Bouchardy, Dorota Butkiewicz, Kwun M. Fong, Manuel Gené, Ari Hirvonen, Chikako Kiyohara, Jill E. Larsen, Pinpin Lin, Ole Raaschou-Nielsen, Andrew C. Povey, Edyta Reszka, Angela Risch, Joachim Schneider, Ann G. Schwartz, Mette Sorensen, Jordi To-FiguerasShinkan Tokudome, Yuepu Pu, Ping Yang, Angela S. Wenzlaff, Harriet Wikman, Emanuela Taioli

Research output: Contribution to journalReview article

62 Citations (Scopus)

Abstract

Lung cancer is the most common cancer worldwide. Polymorphisms in genes associated with carcinogen metabolism may modulate risk of disease. Glutathione S-transferase pi (GSTP1) detoxifies polycyclic aromatic hydrocarbons found in cigarette smoke and is the most highly expressed glutathione S-transferase in lung tissue. A polymorphism in the GSTP1 gene, an A-to-G transition in exon 5 (Ile105Val, 313A → 313G), results in lower activity among individuals who carry the valine allele. The authors present a meta- and a pooled analysis of case-control studies that examined the association between this polymorphism in GSTP1 and lung cancer risk (27 studies, 8,322 cases and 8,844 controls and 15 studies, 4,282 cases and 5,032 controls, respectively). Overall, the meta-analysis found no significant association between lung cancer risk and the GSTP1 exon 5 polymorphism. In the pooled analysis, there was an overall association (odds ratio=1.11, 95% confidence interval: 1.03, 1.21) between lung cancer and carriage of the GSTP1 Val/Val or Ile/Val genotype compared with those carrying the Ile/Ile genotype. Increased risk varied by histologic type in Asians. There appears to be evidence for interaction between amount of smoking, the GSTP1 exon 5 polymorphism, and risk of lung cancer in whites.

Original languageEnglish
Pages (from-to)802-814
Number of pages13
JournalAmerican journal of epidemiology
Volume169
Issue number7
DOIs
Publication statusPublished - Apr 1 2009

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Meta-Analysis
Lung Neoplasms
Exons
Genotype
Glutathione S-Transferase pi
Polycyclic Aromatic Hydrocarbons
Valine
Glutathione Transferase
Smoke
Tobacco Products
Carcinogens
Genes
Case-Control Studies
Smoking
Alleles
Odds Ratio
Confidence Intervals
Lung
Neoplasms

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Cote, M. L., Chen, W., Smith, D. W., Benhamou, S., Bouchardy, C., Butkiewicz, D., ... Taioli, E. (2009). Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: A HuGE-GSEC review. American journal of epidemiology, 169(7), 802-814. https://doi.org/10.1093/aje/kwn417

Meta- and pooled analysis of GSTP1 polymorphism and lung cancer : A HuGE-GSEC review. / Cote, Michele L.; Chen, Wei; Smith, Daryn W.; Benhamou, Simone; Bouchardy, Christine; Butkiewicz, Dorota; Fong, Kwun M.; Gené, Manuel; Hirvonen, Ari; Kiyohara, Chikako; Larsen, Jill E.; Lin, Pinpin; Raaschou-Nielsen, Ole; Povey, Andrew C.; Reszka, Edyta; Risch, Angela; Schneider, Joachim; Schwartz, Ann G.; Sorensen, Mette; To-Figueras, Jordi; Tokudome, Shinkan; Pu, Yuepu; Yang, Ping; Wenzlaff, Angela S.; Wikman, Harriet; Taioli, Emanuela.

In: American journal of epidemiology, Vol. 169, No. 7, 01.04.2009, p. 802-814.

Research output: Contribution to journalReview article

Cote, ML, Chen, W, Smith, DW, Benhamou, S, Bouchardy, C, Butkiewicz, D, Fong, KM, Gené, M, Hirvonen, A, Kiyohara, C, Larsen, JE, Lin, P, Raaschou-Nielsen, O, Povey, AC, Reszka, E, Risch, A, Schneider, J, Schwartz, AG, Sorensen, M, To-Figueras, J, Tokudome, S, Pu, Y, Yang, P, Wenzlaff, AS, Wikman, H & Taioli, E 2009, 'Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: A HuGE-GSEC review', American journal of epidemiology, vol. 169, no. 7, pp. 802-814. https://doi.org/10.1093/aje/kwn417
Cote ML, Chen W, Smith DW, Benhamou S, Bouchardy C, Butkiewicz D et al. Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: A HuGE-GSEC review. American journal of epidemiology. 2009 Apr 1;169(7):802-814. https://doi.org/10.1093/aje/kwn417
Cote, Michele L. ; Chen, Wei ; Smith, Daryn W. ; Benhamou, Simone ; Bouchardy, Christine ; Butkiewicz, Dorota ; Fong, Kwun M. ; Gené, Manuel ; Hirvonen, Ari ; Kiyohara, Chikako ; Larsen, Jill E. ; Lin, Pinpin ; Raaschou-Nielsen, Ole ; Povey, Andrew C. ; Reszka, Edyta ; Risch, Angela ; Schneider, Joachim ; Schwartz, Ann G. ; Sorensen, Mette ; To-Figueras, Jordi ; Tokudome, Shinkan ; Pu, Yuepu ; Yang, Ping ; Wenzlaff, Angela S. ; Wikman, Harriet ; Taioli, Emanuela. / Meta- and pooled analysis of GSTP1 polymorphism and lung cancer : A HuGE-GSEC review. In: American journal of epidemiology. 2009 ; Vol. 169, No. 7. pp. 802-814.
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abstract = "Lung cancer is the most common cancer worldwide. Polymorphisms in genes associated with carcinogen metabolism may modulate risk of disease. Glutathione S-transferase pi (GSTP1) detoxifies polycyclic aromatic hydrocarbons found in cigarette smoke and is the most highly expressed glutathione S-transferase in lung tissue. A polymorphism in the GSTP1 gene, an A-to-G transition in exon 5 (Ile105Val, 313A → 313G), results in lower activity among individuals who carry the valine allele. The authors present a meta- and a pooled analysis of case-control studies that examined the association between this polymorphism in GSTP1 and lung cancer risk (27 studies, 8,322 cases and 8,844 controls and 15 studies, 4,282 cases and 5,032 controls, respectively). Overall, the meta-analysis found no significant association between lung cancer risk and the GSTP1 exon 5 polymorphism. In the pooled analysis, there was an overall association (odds ratio=1.11, 95{\%} confidence interval: 1.03, 1.21) between lung cancer and carriage of the GSTP1 Val/Val or Ile/Val genotype compared with those carrying the Ile/Ile genotype. Increased risk varied by histologic type in Asians. There appears to be evidence for interaction between amount of smoking, the GSTP1 exon 5 polymorphism, and risk of lung cancer in whites.",
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AU - Cote, Michele L.

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AU - Bouchardy, Christine

AU - Butkiewicz, Dorota

AU - Fong, Kwun M.

AU - Gené, Manuel

AU - Hirvonen, Ari

AU - Kiyohara, Chikako

AU - Larsen, Jill E.

AU - Lin, Pinpin

AU - Raaschou-Nielsen, Ole

AU - Povey, Andrew C.

AU - Reszka, Edyta

AU - Risch, Angela

AU - Schneider, Joachim

AU - Schwartz, Ann G.

AU - Sorensen, Mette

AU - To-Figueras, Jordi

AU - Tokudome, Shinkan

AU - Pu, Yuepu

AU - Yang, Ping

AU - Wenzlaff, Angela S.

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