Metabolic gene polymorphism frequencies in control populations

Seymour Garte, Seymour Garte, Laura Gaspari, Anna Karin Alexandrie, Agneta Rannug, Magnus Ingelman-Sundberg, Irene Persson, Christine Ambrosone, Herman Autrup, Judith L. Autrup, Helena Baranova, Lise Bathum, Paolo Boffetta, Katja Breskvar, Vita Dolzan, Jurgen Brockmoller, Ingolf Cascorbi, Margie L. Clapper, Carolyn M. Dresler, Christiane CoutelleAnn Daly, Marco Dell’Omo, Anthony Fryer, Richard C. Strange, Aage Haugen, David Ryberg, David W. Hein, Allan Hildesheim, Ari Hirvonen, Ling Ling Hsieh, Ivan Kalina, Jan Salagovic, Daehee Kang, Masahiro Kihara, Kazumasa Noda, Chikako Kiyohara, Pierre Kremers, Liliane Roelandt, Philip Lazarus, Loéc Le Marchand, Maria Celeste Lechner, Ester M.M. Van Lieshout, Wilbert H.M. Peters, Stephanie London, Johannes J. Manni, Christine M. Maugard, Shunji Morita, Valle Nazar-Stewart, Yoshio Oda, Fritz F. Parl, Roberta Pastorelli, Timothy Rebbeck, Angela Risch, Marjorie Romkes, Bernadette Schoket, Janeric Seidegard, Peter G. Shields, Edith Sim, Daniel Sinnet, Haruhiko Sugimura, Jordi To-Figueras, Paolo Vineis, Mimi C. Yu, Emanuela Taioli

Research output: Contribution to journalArticle

725 Citations (Scopus)

Abstract

Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15, 000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12, 525), Asians (n = 2, 136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.

Original languageEnglish
Pages (from-to)1239-1248
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume10
Issue number12
Publication statusPublished - Jan 1 2001

Fingerprint

Gene Frequency
Environmental Carcinogens
Cytochrome P-450 CYP2E1
Cytochrome P-450 CYP2D6
Cytochrome P-450 CYP1A1
Population Control
Linkage Disequilibrium
Genetic Predisposition to Disease
African Americans
Population
Alleles
Genotype
Databases
Genes

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

Garte, S., Garte, S., Gaspari, L., Alexandrie, A. K., Rannug, A., Ingelman-Sundberg, M., ... Taioli, E. (2001). Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiology Biomarkers and Prevention, 10(12), 1239-1248.

Metabolic gene polymorphism frequencies in control populations. / Garte, Seymour; Garte, Seymour; Gaspari, Laura; Alexandrie, Anna Karin; Rannug, Agneta; Ingelman-Sundberg, Magnus; Persson, Irene; Ambrosone, Christine; Autrup, Herman; Autrup, Judith L.; Baranova, Helena; Bathum, Lise; Boffetta, Paolo; Breskvar, Katja; Dolzan, Vita; Brockmoller, Jurgen; Cascorbi, Ingolf; Clapper, Margie L.; Dresler, Carolyn M.; Coutelle, Christiane; Daly, Ann; Dell’Omo, Marco; Fryer, Anthony; Strange, Richard C.; Haugen, Aage; Ryberg, David; Hein, David W.; Hildesheim, Allan; Hirvonen, Ari; Hsieh, Ling Ling; Kalina, Ivan; Salagovic, Jan; Kang, Daehee; Kihara, Masahiro; Noda, Kazumasa; Kiyohara, Chikako; Kremers, Pierre; Roelandt, Liliane; Lazarus, Philip; Le Marchand, Loéc; Lechner, Maria Celeste; Van Lieshout, Ester M.M.; Peters, Wilbert H.M.; London, Stephanie; Manni, Johannes J.; Maugard, Christine M.; Morita, Shunji; Nazar-Stewart, Valle; Oda, Yoshio; Parl, Fritz F.; Pastorelli, Roberta; Rebbeck, Timothy; Risch, Angela; Romkes, Marjorie; Schoket, Bernadette; Seidegard, Janeric; Shields, Peter G.; Sim, Edith; Sinnet, Daniel; Sugimura, Haruhiko; To-Figueras, Jordi; Vineis, Paolo; Yu, Mimi C.; Taioli, Emanuela.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 10, No. 12, 01.01.2001, p. 1239-1248.

Research output: Contribution to journalArticle

Garte, S, Garte, S, Gaspari, L, Alexandrie, AK, Rannug, A, Ingelman-Sundberg, M, Persson, I, Ambrosone, C, Autrup, H, Autrup, JL, Baranova, H, Bathum, L, Boffetta, P, Breskvar, K, Dolzan, V, Brockmoller, J, Cascorbi, I, Clapper, ML, Dresler, CM, Coutelle, C, Daly, A, Dell’Omo, M, Fryer, A, Strange, RC, Haugen, A, Ryberg, D, Hein, DW, Hildesheim, A, Hirvonen, A, Hsieh, LL, Kalina, I, Salagovic, J, Kang, D, Kihara, M, Noda, K, Kiyohara, C, Kremers, P, Roelandt, L, Lazarus, P, Le Marchand, L, Lechner, MC, Van Lieshout, EMM, Peters, WHM, London, S, Manni, JJ, Maugard, CM, Morita, S, Nazar-Stewart, V, Oda, Y, Parl, FF, Pastorelli, R, Rebbeck, T, Risch, A, Romkes, M, Schoket, B, Seidegard, J, Shields, PG, Sim, E, Sinnet, D, Sugimura, H, To-Figueras, J, Vineis, P, Yu, MC & Taioli, E 2001, 'Metabolic gene polymorphism frequencies in control populations', Cancer Epidemiology Biomarkers and Prevention, vol. 10, no. 12, pp. 1239-1248.
Garte S, Garte S, Gaspari L, Alexandrie AK, Rannug A, Ingelman-Sundberg M et al. Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiology Biomarkers and Prevention. 2001 Jan 1;10(12):1239-1248.
Garte, Seymour ; Garte, Seymour ; Gaspari, Laura ; Alexandrie, Anna Karin ; Rannug, Agneta ; Ingelman-Sundberg, Magnus ; Persson, Irene ; Ambrosone, Christine ; Autrup, Herman ; Autrup, Judith L. ; Baranova, Helena ; Bathum, Lise ; Boffetta, Paolo ; Breskvar, Katja ; Dolzan, Vita ; Brockmoller, Jurgen ; Cascorbi, Ingolf ; Clapper, Margie L. ; Dresler, Carolyn M. ; Coutelle, Christiane ; Daly, Ann ; Dell’Omo, Marco ; Fryer, Anthony ; Strange, Richard C. ; Haugen, Aage ; Ryberg, David ; Hein, David W. ; Hildesheim, Allan ; Hirvonen, Ari ; Hsieh, Ling Ling ; Kalina, Ivan ; Salagovic, Jan ; Kang, Daehee ; Kihara, Masahiro ; Noda, Kazumasa ; Kiyohara, Chikako ; Kremers, Pierre ; Roelandt, Liliane ; Lazarus, Philip ; Le Marchand, Loéc ; Lechner, Maria Celeste ; Van Lieshout, Ester M.M. ; Peters, Wilbert H.M. ; London, Stephanie ; Manni, Johannes J. ; Maugard, Christine M. ; Morita, Shunji ; Nazar-Stewart, Valle ; Oda, Yoshio ; Parl, Fritz F. ; Pastorelli, Roberta ; Rebbeck, Timothy ; Risch, Angela ; Romkes, Marjorie ; Schoket, Bernadette ; Seidegard, Janeric ; Shields, Peter G. ; Sim, Edith ; Sinnet, Daniel ; Sugimura, Haruhiko ; To-Figueras, Jordi ; Vineis, Paolo ; Yu, Mimi C. ; Taioli, Emanuela. / Metabolic gene polymorphism frequencies in control populations. In: Cancer Epidemiology Biomarkers and Prevention. 2001 ; Vol. 10, No. 12. pp. 1239-1248.
@article{2a0fccd0fbfc49fbacf8919ddf878f2b,
title = "Metabolic gene polymorphism frequencies in control populations",
abstract = "Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15, 000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12, 525), Asians (n = 2, 136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.",
author = "Seymour Garte and Seymour Garte and Laura Gaspari and Alexandrie, {Anna Karin} and Agneta Rannug and Magnus Ingelman-Sundberg and Irene Persson and Christine Ambrosone and Herman Autrup and Autrup, {Judith L.} and Helena Baranova and Lise Bathum and Paolo Boffetta and Katja Breskvar and Vita Dolzan and Jurgen Brockmoller and Ingolf Cascorbi and Clapper, {Margie L.} and Dresler, {Carolyn M.} and Christiane Coutelle and Ann Daly and Marco Dell’Omo and Anthony Fryer and Strange, {Richard C.} and Aage Haugen and David Ryberg and Hein, {David W.} and Allan Hildesheim and Ari Hirvonen and Hsieh, {Ling Ling} and Ivan Kalina and Jan Salagovic and Daehee Kang and Masahiro Kihara and Kazumasa Noda and Chikako Kiyohara and Pierre Kremers and Liliane Roelandt and Philip Lazarus and {Le Marchand}, Lo{\'e}c and Lechner, {Maria Celeste} and {Van Lieshout}, {Ester M.M.} and Peters, {Wilbert H.M.} and Stephanie London and Manni, {Johannes J.} and Maugard, {Christine M.} and Shunji Morita and Valle Nazar-Stewart and Yoshio Oda and Parl, {Fritz F.} and Roberta Pastorelli and Timothy Rebbeck and Angela Risch and Marjorie Romkes and Bernadette Schoket and Janeric Seidegard and Shields, {Peter G.} and Edith Sim and Daniel Sinnet and Haruhiko Sugimura and Jordi To-Figueras and Paolo Vineis and Yu, {Mimi C.} and Emanuela Taioli",
year = "2001",
month = "1",
day = "1",
language = "English",
volume = "10",
pages = "1239--1248",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "12",

}

TY - JOUR

T1 - Metabolic gene polymorphism frequencies in control populations

AU - Garte, Seymour

AU - Garte, Seymour

AU - Gaspari, Laura

AU - Alexandrie, Anna Karin

AU - Rannug, Agneta

AU - Ingelman-Sundberg, Magnus

AU - Persson, Irene

AU - Ambrosone, Christine

AU - Autrup, Herman

AU - Autrup, Judith L.

AU - Baranova, Helena

AU - Bathum, Lise

AU - Boffetta, Paolo

AU - Breskvar, Katja

AU - Dolzan, Vita

AU - Brockmoller, Jurgen

AU - Cascorbi, Ingolf

AU - Clapper, Margie L.

AU - Dresler, Carolyn M.

AU - Coutelle, Christiane

AU - Daly, Ann

AU - Dell’Omo, Marco

AU - Fryer, Anthony

AU - Strange, Richard C.

AU - Haugen, Aage

AU - Ryberg, David

AU - Hein, David W.

AU - Hildesheim, Allan

AU - Hirvonen, Ari

AU - Hsieh, Ling Ling

AU - Kalina, Ivan

AU - Salagovic, Jan

AU - Kang, Daehee

AU - Kihara, Masahiro

AU - Noda, Kazumasa

AU - Kiyohara, Chikako

AU - Kremers, Pierre

AU - Roelandt, Liliane

AU - Lazarus, Philip

AU - Le Marchand, Loéc

AU - Lechner, Maria Celeste

AU - Van Lieshout, Ester M.M.

AU - Peters, Wilbert H.M.

AU - London, Stephanie

AU - Manni, Johannes J.

AU - Maugard, Christine M.

AU - Morita, Shunji

AU - Nazar-Stewart, Valle

AU - Oda, Yoshio

AU - Parl, Fritz F.

AU - Pastorelli, Roberta

AU - Rebbeck, Timothy

AU - Risch, Angela

AU - Romkes, Marjorie

AU - Schoket, Bernadette

AU - Seidegard, Janeric

AU - Shields, Peter G.

AU - Sim, Edith

AU - Sinnet, Daniel

AU - Sugimura, Haruhiko

AU - To-Figueras, Jordi

AU - Vineis, Paolo

AU - Yu, Mimi C.

AU - Taioli, Emanuela

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15, 000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12, 525), Asians (n = 2, 136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.

AB - Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15, 000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12, 525), Asians (n = 2, 136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.

UR - http://www.scopus.com/inward/record.url?scp=0035660166&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035660166&partnerID=8YFLogxK

M3 - Article

C2 - 11751440

AN - SCOPUS:0035660166

VL - 10

SP - 1239

EP - 1248

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 12

ER -