Metabolic gene polymorphism frequencies in control populations

Seymour Garte, Seymour Garte, Laura Gaspari, Anna Karin Alexandrie, Agneta Rannug, Magnus Ingelman-Sundberg, Irene Persson, Christine Ambrosone, Herman Autrup, Judith L. Autrup, Helena Baranova, Lise Bathum, Paolo Boffetta, Katja Breskvar, Vita Dolzan, Jurgen Brockmoller, Ingolf Cascorbi, Margie L. Clapper, Carolyn M. Dresler, Christiane CoutelleAnn Daly, Marco Dell’Omo, Anthony Fryer, Richard C. Strange, Aage Haugen, David Ryberg, David W. Hein, Allan Hildesheim, Ari Hirvonen, Ling Ling Hsieh, Ivan Kalina, Jan Salagovic, Daehee Kang, Masahiro Kihara, Kazumasa Noda, Chikako Kiyohara, Pierre Kremers, Liliane Roelandt, Philip Lazarus, Loéc Le Marchand, Maria Celeste Lechner, Ester M.M. Van Lieshout, Wilbert H.M. Peters, Stephanie London, Johannes J. Manni, Christine M. Maugard, Shunji Morita, Valle Nazar-Stewart, Yoshio Oda, Fritz F. Parl, Roberta Pastorelli, Timothy Rebbeck, Angela Risch, Marjorie Romkes, Bernadette Schoket, Janeric Seidegard, Peter G. Shields, Edith Sim, Daniel Sinnet, Haruhiko Sugimura, Jordi To-Figueras, Paolo Vineis, Mimi C. Yu, Emanuela Taioli

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Abstract

Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15, 000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12, 525), Asians (n = 2, 136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.

Original languageEnglish
Pages (from-to)1239-1248
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume10
Issue number12
Publication statusPublished - Jan 1 2001

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All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

Garte, S., Garte, S., Gaspari, L., Alexandrie, A. K., Rannug, A., Ingelman-Sundberg, M., ... Taioli, E. (2001). Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiology Biomarkers and Prevention, 10(12), 1239-1248.