Metabolic Pathway of 2-Deoxy-2-fluoro-D-glucose and 2-Deoxy-2-fluoro-D-mannose in Mice Bearing Sarcoma 180 Studied by Fluorin-19 Nuclear Magnetic Resonance

Masaharu Kojima, Satoru Kuribayashi, Yoko Kanazawa, Terushi Haradahira, Yoshihiko Maehara, Hideya Endo

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The metabolic products of 2-deoxy-2-fluoro-D-glucose (FDG) and 2-deoxy-2-fluoro-D-mannose (FDM) in sarcoma 180 cells transplanted in mice were investigated by fluorin-19 nuclear magnetic resonance (19F-NMR) spectroscopy. It became apparent that the administered FDG was converted to FDM (and/or FDM-6-phosphate) in tumor cells, and also the administered FDM was converted to FDG (and/or FDG-6-phosphate). At 9h after administration of FDM, the ratio of FDG (and/or FDG-6-phosphate) and FDM (and/or FDM-6-phosphate) reached equilibrium. On the other hand, it took more than 48 h in the case of FDG administration. The equilibrium amount of FDM (and/or FDM-6-phosphate) was approximately four times as much as that of FDG (and/or FDG-6-phosphate) in both cases.

Original languageEnglish
Pages (from-to)1194-1197
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume36
Issue number3
DOIs
Publication statusPublished - Jan 1 1988

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Bearings (structural)
Sarcoma 180
Fluorodeoxyglucose F18
Mannose
Metabolic Networks and Pathways
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Glucose
Glucose-6-Phosphate
Magnetic resonance spectroscopy
2-deoxy-2-fluoromannose
Nuclear magnetic resonance spectroscopy
Tumors
Cells

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Cite this

Metabolic Pathway of 2-Deoxy-2-fluoro-D-glucose and 2-Deoxy-2-fluoro-D-mannose in Mice Bearing Sarcoma 180 Studied by Fluorin-19 Nuclear Magnetic Resonance. / Kojima, Masaharu; Kuribayashi, Satoru; Kanazawa, Yoko; Haradahira, Terushi; Maehara, Yoshihiko; Endo, Hideya.

In: Chemical and Pharmaceutical Bulletin, Vol. 36, No. 3, 01.01.1988, p. 1194-1197.

Research output: Contribution to journalArticle

Kojima, Masaharu ; Kuribayashi, Satoru ; Kanazawa, Yoko ; Haradahira, Terushi ; Maehara, Yoshihiko ; Endo, Hideya. / Metabolic Pathway of 2-Deoxy-2-fluoro-D-glucose and 2-Deoxy-2-fluoro-D-mannose in Mice Bearing Sarcoma 180 Studied by Fluorin-19 Nuclear Magnetic Resonance. In: Chemical and Pharmaceutical Bulletin. 1988 ; Vol. 36, No. 3. pp. 1194-1197.
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abstract = "The metabolic products of 2-deoxy-2-fluoro-D-glucose (FDG) and 2-deoxy-2-fluoro-D-mannose (FDM) in sarcoma 180 cells transplanted in mice were investigated by fluorin-19 nuclear magnetic resonance (19F-NMR) spectroscopy. It became apparent that the administered FDG was converted to FDM (and/or FDM-6-phosphate) in tumor cells, and also the administered FDM was converted to FDG (and/or FDG-6-phosphate). At 9h after administration of FDM, the ratio of FDG (and/or FDG-6-phosphate) and FDM (and/or FDM-6-phosphate) reached equilibrium. On the other hand, it took more than 48 h in the case of FDG administration. The equilibrium amount of FDM (and/or FDM-6-phosphate) was approximately four times as much as that of FDG (and/or FDG-6-phosphate) in both cases.",
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