Metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil to 5-fluorouracil in partially hepatectomized rats

Y. Maehara; I. Takahashi; M. Yoshida; Y. Emi; H. Baba; H. Kusumoto; S. Kohnoe; K. Sugimachi

doi:10.1097/00001813-199204000-00007

Metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil to 5-fluorouracil in partially hepatectomized rats

Y. Maehara, I. Takahashi, M. Yoshida, Y. Emi, H. Baba, H. Kusumoto, S. Kohnoe, K. Sugimachi

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Abstract

Changes in the metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil (tegafur) to 5-fluorouracil (5-FU) were examined in the plasma, lung, liver, stomach, small intestine, spleen and kidney in two-thirds partially hepatectomized rats. Concentrations of tegafur and 5-FU in plasma and tissues were determined 30 min after injecting 100 mg/kg of tegafur via the tail vein. The 5-FU concentration in the plasma remained unchanged for the first 7 days after hepatectomy. The tissue level of 5-FU was higher in the liver and kidney than in other organs examined, but there were no changes in levels of 5-FU in each organ examined. Our observations support the proposal that the conversion of tegafur to 5-FU is maintained in partially hepatectomized rats.

Original language	English
Pages (from-to)	117-120
Number of pages	4
Journal	Anti-cancer drugs
Volume	3
Issue number	2
DOIs	https://doi.org/10.1097/00001813-199204000-00007
Publication status	Published - Jan 1 1992

All Science Journal Classification (ASJC) codes

Oncology
Pharmacology
Pharmacology (medical)
Cancer Research

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10.1097/00001813-199204000-00007

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title = "Metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil to 5-fluorouracil in partially hepatectomized rats",

abstract = "Changes in the metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil (tegafur) to 5-fluorouracil (5-FU) were examined in the plasma, lung, liver, stomach, small intestine, spleen and kidney in two-thirds partially hepatectomized rats. Concentrations of tegafur and 5-FU in plasma and tissues were determined 30 min after injecting 100 mg/kg of tegafur via the tail vein. The 5-FU concentration in the plasma remained unchanged for the first 7 days after hepatectomy. The tissue level of 5-FU was higher in the liver and kidney than in other organs examined, but there were no changes in levels of 5-FU in each organ examined. Our observations support the proposal that the conversion of tegafur to 5-FU is maintained in partially hepatectomized rats.",

author = "Y. Maehara and I. Takahashi and M. Yoshida and Y. Emi and H. Baba and H. Kusumoto and S. Kohnoe and K. Sugimachi",

year = "1992",

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doi = "10.1097/00001813-199204000-00007",

language = "English",

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T1 - Metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil to 5-fluorouracil in partially hepatectomized rats

AU - Maehara, Y.

AU - Takahashi, I.

AU - Yoshida, M.

AU - Emi, Y.

AU - Baba, H.

AU - Kusumoto, H.

AU - Kohnoe, S.

AU - Sugimachi, K.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Changes in the metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil (tegafur) to 5-fluorouracil (5-FU) were examined in the plasma, lung, liver, stomach, small intestine, spleen and kidney in two-thirds partially hepatectomized rats. Concentrations of tegafur and 5-FU in plasma and tissues were determined 30 min after injecting 100 mg/kg of tegafur via the tail vein. The 5-FU concentration in the plasma remained unchanged for the first 7 days after hepatectomy. The tissue level of 5-FU was higher in the liver and kidney than in other organs examined, but there were no changes in levels of 5-FU in each organ examined. Our observations support the proposal that the conversion of tegafur to 5-FU is maintained in partially hepatectomized rats.

AB - Changes in the metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil (tegafur) to 5-fluorouracil (5-FU) were examined in the plasma, lung, liver, stomach, small intestine, spleen and kidney in two-thirds partially hepatectomized rats. Concentrations of tegafur and 5-FU in plasma and tissues were determined 30 min after injecting 100 mg/kg of tegafur via the tail vein. The 5-FU concentration in the plasma remained unchanged for the first 7 days after hepatectomy. The tissue level of 5-FU was higher in the liver and kidney than in other organs examined, but there were no changes in levels of 5-FU in each organ examined. Our observations support the proposal that the conversion of tegafur to 5-FU is maintained in partially hepatectomized rats.

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JO - Anti-Cancer Drugs

JF - Anti-Cancer Drugs

IS - 2

ER -

Metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil to 5-fluorouracil in partially hepatectomized rats

Abstract

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