Abstract
Abuse of drugs remains a serious and world-wide problem. As exemplified by opioids, there are large inter-individual differences in the effects and toxicity of drugs. However, the mechanism underlying such inter-individual differences remains largely unknown. Since, in many cases, drug metabolism affects the effects of drugs, the different metabolic capacity of individuals may explain these inter-individual differences. In this review, we shall focus on drugs of abuse and survey briefly their metabolism and the enzymes involved. In addition, we shall discuss the putative origin of the inter-individual differences in sensitivity to drugs of abuse.
| Original language | English |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | Journal of Health Science |
| Volume | 51 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - May 18 2005 |
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All Science Journal Classification (ASJC) codes
- Toxicology
- Health, Toxicology and Mutagenesis
Cite this
Metabolism of drugs of abuse : Its contribution to the toxicity and the inter-individual differences in drug sensitivity. / Yamada, Hideyuki; Ishii, Yuji; Oguri, Kazuta.
In: Journal of Health Science, Vol. 51, No. 1, 18.05.2005, p. 1-7.Research output: Contribution to journal › Short survey
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TY - JOUR
T1 - Metabolism of drugs of abuse
T2 - Its contribution to the toxicity and the inter-individual differences in drug sensitivity
AU - Yamada, Hideyuki
AU - Ishii, Yuji
AU - Oguri, Kazuta
PY - 2005/5/18
Y1 - 2005/5/18
N2 - Abuse of drugs remains a serious and world-wide problem. As exemplified by opioids, there are large inter-individual differences in the effects and toxicity of drugs. However, the mechanism underlying such inter-individual differences remains largely unknown. Since, in many cases, drug metabolism affects the effects of drugs, the different metabolic capacity of individuals may explain these inter-individual differences. In this review, we shall focus on drugs of abuse and survey briefly their metabolism and the enzymes involved. In addition, we shall discuss the putative origin of the inter-individual differences in sensitivity to drugs of abuse.
AB - Abuse of drugs remains a serious and world-wide problem. As exemplified by opioids, there are large inter-individual differences in the effects and toxicity of drugs. However, the mechanism underlying such inter-individual differences remains largely unknown. Since, in many cases, drug metabolism affects the effects of drugs, the different metabolic capacity of individuals may explain these inter-individual differences. In this review, we shall focus on drugs of abuse and survey briefly their metabolism and the enzymes involved. In addition, we shall discuss the putative origin of the inter-individual differences in sensitivity to drugs of abuse.
UR - http://www.scopus.com/inward/record.url?scp=18244376098&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18244376098&partnerID=8YFLogxK
U2 - 10.1248/jhs.51.1
DO - 10.1248/jhs.51.1
M3 - Short survey
AN - SCOPUS:18244376098
VL - 51
SP - 1
EP - 7
JO - Journal of Health Science
JF - Journal of Health Science
SN - 1344-9702
IS - 1
ER -