TY - JOUR
T1 - Metabolism of drugs of abuse
T2 - Its contribution to the toxicity and the inter-individual differences in drug sensitivity
AU - Yamada, Hideyuki
AU - Ishii, Yuji
AU - Oguri, Kazuta
PY - 2005
Y1 - 2005
N2 - Abuse of drugs remains a serious and world-wide problem. As exemplified by opioids, there are large inter-individual differences in the effects and toxicity of drugs. However, the mechanism underlying such inter-individual differences remains largely unknown. Since, in many cases, drug metabolism affects the effects of drugs, the different metabolic capacity of individuals may explain these inter-individual differences. In this review, we shall focus on drugs of abuse and survey briefly their metabolism and the enzymes involved. In addition, we shall discuss the putative origin of the inter-individual differences in sensitivity to drugs of abuse.
AB - Abuse of drugs remains a serious and world-wide problem. As exemplified by opioids, there are large inter-individual differences in the effects and toxicity of drugs. However, the mechanism underlying such inter-individual differences remains largely unknown. Since, in many cases, drug metabolism affects the effects of drugs, the different metabolic capacity of individuals may explain these inter-individual differences. In this review, we shall focus on drugs of abuse and survey briefly their metabolism and the enzymes involved. In addition, we shall discuss the putative origin of the inter-individual differences in sensitivity to drugs of abuse.
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U2 - 10.1248/jhs.51.1
DO - 10.1248/jhs.51.1
M3 - Short survey
AN - SCOPUS:18244376098
VL - 51
SP - 1
EP - 7
JO - Journal of Health Science
JF - Journal of Health Science
SN - 1344-9702
IS - 1
ER -