Metabolism of tributyltin and triphenyltin by Dall's porpoise hepatic microsomes

Jian Yang, Yuji Oshima, Ito Sei, Nobuyuki Miyazaki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The in vitro metabolism of tributyltin (TBT) and triphenyltin (TPT) by the hepatic microsomal cytochrome P-450 system enzymes of Dall's porpoises (Phocoenoides dalli) was comparatively elucidated with those enzymes of the Sprague Dawley rat in the present study. Our results suggested firstly a limited metabolic capacity for TBT and especially TPT to their metabolites in the Dall's porpoises, and documented a similar mechanism of a relatively stronger metabolic rate of TBT to its metabolites than that of TPT in the microsome of porpoises and rat. However, the metabolic capacity to degrade both TBT and TPT were much lower in the microsome of porpoises than that in the rats.

Original languageEnglish
Pages (from-to)1013-1015
Number of pages3
JournalChemosphere
Volume76
Issue number7
DOIs
Publication statusPublished - Aug 1 2009

Fingerprint

Porpoises
porpoise
tributyltin
Microsomes
Metabolism
Rats
metabolism
Metabolites
Liver
metabolite
enzyme
Enzymes
Cytochrome P-450 Enzyme System
cytochrome
Sprague Dawley Rats
triphenyltin

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Metabolism of tributyltin and triphenyltin by Dall's porpoise hepatic microsomes. / Yang, Jian; Oshima, Yuji; Sei, Ito; Miyazaki, Nobuyuki.

In: Chemosphere, Vol. 76, No. 7, 01.08.2009, p. 1013-1015.

Research output: Contribution to journalArticle

Yang, Jian ; Oshima, Yuji ; Sei, Ito ; Miyazaki, Nobuyuki. / Metabolism of tributyltin and triphenyltin by Dall's porpoise hepatic microsomes. In: Chemosphere. 2009 ; Vol. 76, No. 7. pp. 1013-1015.
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