TY - JOUR
T1 - Metabolomic analysis reveals metabolic alterations of human peripheral blood lymphocytes by perfluorooctanoic acid
AU - Li, Rong
AU - Guo, Chao
AU - Tse, William Ka Fai
AU - Su, Min
AU - Zhang, Xiaoxi
AU - Lai, Keng Po
N1 - Funding Information:
This study was supported by grants from the National Natural Science Foundation of China (No. 81560134 , 81660091 , 81860097 ) and the National Natural Science Foundation of Guangxi (No. 2018GXNSFAA281153 , 2018GXNSFAA281242 ). The environmental research work in Tse's lab is partially funded by the Kurita Water and Environment Foundation ( 18B004 , 17E003 ).
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/1
Y1 - 2020/1
N2 - Perfluorooctanoic acid (PFOA) is a dispersive persistent organic pollutant in the environment. Accumulating reports suggest that PFOA is toxic to human lymphocytes; however, the toxicological effects of PFOA on these cells remain largely unclear. In this study, ultra-performance liquid chromatography (UPLC)-based metabolomic analysis was employed to identify metabolites in human peripheral blood lymphocytes and to assess the metabolic alterations caused by PFOA exposure. Our comparative metabolomic analysis results demonstrated that PFOA treatment could increase the level of organic acids and reduce the level of lipid molecules. Kyoto Encyclopedia of Genes and Genomes (KEGG) annotation further highlighted the fact that the PFOA treatment interfered with the metabolism of amino acids, carbohydrates and lipids, which may lead to disruption of the immune system.
AB - Perfluorooctanoic acid (PFOA) is a dispersive persistent organic pollutant in the environment. Accumulating reports suggest that PFOA is toxic to human lymphocytes; however, the toxicological effects of PFOA on these cells remain largely unclear. In this study, ultra-performance liquid chromatography (UPLC)-based metabolomic analysis was employed to identify metabolites in human peripheral blood lymphocytes and to assess the metabolic alterations caused by PFOA exposure. Our comparative metabolomic analysis results demonstrated that PFOA treatment could increase the level of organic acids and reduce the level of lipid molecules. Kyoto Encyclopedia of Genes and Genomes (KEGG) annotation further highlighted the fact that the PFOA treatment interfered with the metabolism of amino acids, carbohydrates and lipids, which may lead to disruption of the immune system.
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U2 - 10.1016/j.chemosphere.2019.124810
DO - 10.1016/j.chemosphere.2019.124810
M3 - Article
C2 - 31520980
AN - SCOPUS:85071974088
SN - 0045-6535
VL - 239
JO - Chemosphere
JF - Chemosphere
M1 - 124810
ER -