Metabolomic analysis reveals metabolic alterations of human peripheral blood lymphocytes by perfluorooctanoic acid

Rong Li, Chao Guo, Ka Fai William Tse, Min Su, Xiaoxi Zhang, Keng Po Lai

Research output: Contribution to journalArticle

Abstract

Perfluorooctanoic acid (PFOA) is a dispersive persistent organic pollutant in the environment. Accumulating reports suggest that PFOA is toxic to human lymphocytes; however, the toxicological effects of PFOA on these cells remain largely unclear. In this study, ultra-performance liquid chromatography (UPLC)-based metabolomic analysis was employed to identify metabolites in human peripheral blood lymphocytes and to assess the metabolic alterations caused by PFOA exposure. Our comparative metabolomic analysis results demonstrated that PFOA treatment could increase the level of organic acids and reduce the level of lipid molecules. Kyoto Encyclopedia of Genes and Genomes (KEGG) annotation further highlighted the fact that the PFOA treatment interfered with the metabolism of amino acids, carbohydrates and lipids, which may lead to disruption of the immune system.

Original languageEnglish
Article number124810
JournalChemosphere
Volume239
DOIs
Publication statusPublished - Jan 1 2020

Fingerprint

perfluorooctanoic acid
Metabolomics
Lymphocytes
Blood
blood
Acids
acid
Lipids
Genes
lipid
Encyclopedias
Molecular Sequence Annotation
Organic pollutants
Immune system
Poisons
Organic acids
Liquid chromatography
immune system
Carbohydrates
Metabolites

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Metabolomic analysis reveals metabolic alterations of human peripheral blood lymphocytes by perfluorooctanoic acid. / Li, Rong; Guo, Chao; Tse, Ka Fai William; Su, Min; Zhang, Xiaoxi; Lai, Keng Po.

In: Chemosphere, Vol. 239, 124810, 01.01.2020.

Research output: Contribution to journalArticle

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