Metal-ion-assisted hydrolysis of dipeptides involving a serine residue in a neutral aqueous solution

Morio Yashiro, Yoko Sonobe, Ai Yamamura, Tohru Takarada, Makoto Komiyama, Yuki Fujii

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Dipeptides having a serine residue at the C-terminus, X-Ser, where X is an appropriate amino acid residue, were efficiently hydrolyzed in the presence of ZnCl2 at pH 7.0. The rapid hydrolysis of X-Ser is due to an autocatalysis of the hydroxy group in the serine residue, and is found to be accelerated by a metal ion, in particular by ZnCl2. Roles of the metal ion in the hydrolysis of peptides involving a serine residue, in relation to the recently reported protein cleavages, are discussed.

Original languageEnglish
Pages (from-to)629-632
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume1
Issue number4
DOIs
Publication statusPublished - Feb 21 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Metal-ion-assisted hydrolysis of dipeptides involving a serine residue in a neutral aqueous solution'. Together they form a unique fingerprint.

  • Cite this