Methamphetamine-induced sensitization of dopamine release via a metabotropic glutamate receptor mediated pathway in rat striatal slices

Ikumi Arai, Takao Shimazoe, Shigenobu Shibata, Hirotaka Inoue, Akiko Yoshimatsu, Shigenori Watanabe

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We studied the roles of metabotropic glutamate receptors in methamphetamine (MAP)-induced sensitization of dopamine (DA) release from striatal slices. Rats were first treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days. After a 6-day withdrawal, DA release from striatal slices evoked by ±-1-aminocyclopentane-trans-1,3-dicarboxylic acid (trans-ACPD) was measured. trans-ACPD-induced DA release was significantly enhanced in MAP-sensitized rats, but the inactive form of trans-ACPD (1R,3S-ACPD) did not enhance DA release. The active form of trans-ACPD (1S,3R-ACPD) (0.1 mM)-evoked DA release was attenuated by treatment with 0.4 mM RS-α-methyl-4-carboxyphenylglycine, a metabotropic glutamate receptor antagonist. The present results suggest that metabotropic glutamate receptors play an important role in expression of MAP-induced sensitization.

Original languageEnglish
Pages (from-to)243-246
Number of pages4
JournalJapanese Journal of Pharmacology
Volume73
Issue number3
DOIs
Publication statusPublished - Jan 1 1997

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Corpus Striatum
Metabotropic Glutamate Receptors
Methamphetamine
Dopamine
Excitatory Amino Acid Antagonists
1-amino-1,3-dicarboxycyclopentane

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Methamphetamine-induced sensitization of dopamine release via a metabotropic glutamate receptor mediated pathway in rat striatal slices. / Arai, Ikumi; Shimazoe, Takao; Shibata, Shigenobu; Inoue, Hirotaka; Yoshimatsu, Akiko; Watanabe, Shigenori.

In: Japanese Journal of Pharmacology, Vol. 73, No. 3, 01.01.1997, p. 243-246.

Research output: Contribution to journalArticle

Arai, Ikumi ; Shimazoe, Takao ; Shibata, Shigenobu ; Inoue, Hirotaka ; Yoshimatsu, Akiko ; Watanabe, Shigenori. / Methamphetamine-induced sensitization of dopamine release via a metabotropic glutamate receptor mediated pathway in rat striatal slices. In: Japanese Journal of Pharmacology. 1997 ; Vol. 73, No. 3. pp. 243-246.
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