Method for a convenient and efficient synthesis of amino acid acrylic monomers with zwitterionic structure

Shoji Nagaoka, Atsuomi Shundo, Takao Satoh, Kazuhiko Nagira, Ryoich Kishi, Katsuhiko Ueno, Kokoro Iio, Hirotaka Ihara

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Ampholyte monomers with zwitterionic moiety derived from α-amino acid, that is, L-lysine and L-serine, were obtained using a method in which their copper complexes could be produced in simple steps. The N-acryloylation of L-lysine and L-serine was carried out by reaction between their copper complexes and acryloyl chloride. Specifically, the removal of copper from the copper complex of acryloyl amino acid through the use of 8-hydroxyquinoline as an organic chelate precipitant increased the yield of the ampholyte monomers with zwitterionic moiety. These syntheses were easily carried out in a three-step procedure.

Original languageEnglish
Pages (from-to)2529-2534
Number of pages6
JournalSynthetic Communications
Volume35
Issue number19
DOIs
Publication statusPublished - 2005
Externally publishedYes

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Acrylic monomers
Copper
Amino Acids
Serine
Lysine
Buffers
Monomers
Oxyquinoline

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

Method for a convenient and efficient synthesis of amino acid acrylic monomers with zwitterionic structure. / Nagaoka, Shoji; Shundo, Atsuomi; Satoh, Takao; Nagira, Kazuhiko; Kishi, Ryoich; Ueno, Katsuhiko; Iio, Kokoro; Ihara, Hirotaka.

In: Synthetic Communications, Vol. 35, No. 19, 2005, p. 2529-2534.

Research output: Contribution to journalArticle

Nagaoka, Shoji ; Shundo, Atsuomi ; Satoh, Takao ; Nagira, Kazuhiko ; Kishi, Ryoich ; Ueno, Katsuhiko ; Iio, Kokoro ; Ihara, Hirotaka. / Method for a convenient and efficient synthesis of amino acid acrylic monomers with zwitterionic structure. In: Synthetic Communications. 2005 ; Vol. 35, No. 19. pp. 2529-2534.
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AU - Iio, Kokoro

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