Method for a convenient and efficient synthesis of amino acid acrylic monomers with zwitterionic structure

Shoji Nagaoka, Atsuomi Shundo, Takao Satoh, Kazuhiko Nagira, Ryoich Kishi, Katsuhiko Ueno, Kokoro Iio, Hirotaka Ihara

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Ampholyte monomers with zwitterionic moiety derived from α-amino acid, that is, L-lysine and L-serine, were obtained using a method in which their copper complexes could be produced in simple steps. The N-acryloylation of L-lysine and L-serine was carried out by reaction between their copper complexes and acryloyl chloride. Specifically, the removal of copper from the copper complex of acryloyl amino acid through the use of 8-hydroxyquinoline as an organic chelate precipitant increased the yield of the ampholyte monomers with zwitterionic moiety. These syntheses were easily carried out in a three-step procedure.

Original languageEnglish
Pages (from-to)2529-2534
Number of pages6
JournalSynthetic Communications
Volume35
Issue number19
DOIs
Publication statusPublished - 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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