Methotrexate-related lymphoproliferative disorder presenting with severe swelling of the elbow joint

Takashi Hatano; Masanobu Ohishi; Goichi Yoshimoto; Moriyasu Yamauchi; Akira Maekawa; Hidetaka Yamamoto; Yoshinao Oda; Makoto Endo; Hirofumi Bekki; Tomoya Matsunobu; Yasuharu Nakashima; Ken Okazaki; Jun Ichi Fukushi; Akiko Oyamada; Yukihide Iwamoto

doi:10.2106/JBJS.CC.17.00002

Methotrexate-related lymphoproliferative disorder presenting with severe swelling of the elbow joint

Takashi Hatano, Masanobu Ohishi, Goichi Yoshimoto, Moriyasu Yamauchi, Akira Maekawa, Hidetaka Yamamoto, Yoshinao Oda, Makoto Endo, Hirofumi Bekki, Tomoya Matsunobu, Yasuharu Nakashima, Ken Okazaki, Jun Ichi Fukushi, Akiko Oyamada, Yukihide Iwamoto

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Case: A patient with rheumatoid arthritis (RA) who was being treated with methotrexate (MTX) therapy presented with severe swelling of the left elbow. Magnetic resonance imaging showed a tumor-like lesion around the elbow joint. Fluorodeoxyglucose positron emission tomography indicated multiple lesions in the lung and the lymph nodes. An open biopsy of a cervical lymph node was performed, and MTX-related lymphoproliferative disorder (MTX-LPD) was diagnosed. After cessation of the MTX therapy, the elbow swelling regressed, and the patient was in remission of MTX-LPD. Conclusion: MTX-LPD should be considered in the differential diagnosis when a patient with RA develops severe joint swelling while on MTX therapy.

Original language	English
Article number	e65
Journal	JBJS case connector
Volume	7
Issue number	3
DOIs	https://doi.org/10.2106/JBJS.CC.17.00002
Publication status	Published - 2017

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.2106/JBJS.CC.17.00002

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Hatano, T., Ohishi, M., Yoshimoto, G., Yamauchi, M., Maekawa, A., Yamamoto, H., Oda, Y., Endo, M., Bekki, H., Matsunobu, T., Nakashima, Y., Okazaki, K., Fukushi, J. I., Oyamada, A., & Iwamoto, Y. (2017). Methotrexate-related lymphoproliferative disorder presenting with severe swelling of the elbow joint. JBJS case connector, 7(3), [e65]. https://doi.org/10.2106/JBJS.CC.17.00002

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title = "Methotrexate-related lymphoproliferative disorder presenting with severe swelling of the elbow joint",

abstract = "Case: A patient with rheumatoid arthritis (RA) who was being treated with methotrexate (MTX) therapy presented with severe swelling of the left elbow. Magnetic resonance imaging showed a tumor-like lesion around the elbow joint. Fluorodeoxyglucose positron emission tomography indicated multiple lesions in the lung and the lymph nodes. An open biopsy of a cervical lymph node was performed, and MTX-related lymphoproliferative disorder (MTX-LPD) was diagnosed. After cessation of the MTX therapy, the elbow swelling regressed, and the patient was in remission of MTX-LPD. Conclusion: MTX-LPD should be considered in the differential diagnosis when a patient with RA develops severe joint swelling while on MTX therapy.",

author = "Takashi Hatano and Masanobu Ohishi and Goichi Yoshimoto and Moriyasu Yamauchi and Akira Maekawa and Hidetaka Yamamoto and Yoshinao Oda and Makoto Endo and Hirofumi Bekki and Tomoya Matsunobu and Yasuharu Nakashima and Ken Okazaki and Fukushi, {Jun Ichi} and Akiko Oyamada and Yukihide Iwamoto",

note = "Publisher Copyright: {\textcopyright} 2017 By The Journal of Bone and Joint Surgery, Incorporated.",

year = "2017",

doi = "10.2106/JBJS.CC.17.00002",

language = "English",

volume = "7",

journal = "JBJS Case Connector",

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TY - JOUR

T1 - Methotrexate-related lymphoproliferative disorder presenting with severe swelling of the elbow joint

AU - Hatano, Takashi

AU - Ohishi, Masanobu

AU - Yoshimoto, Goichi

AU - Yamauchi, Moriyasu

AU - Maekawa, Akira

AU - Yamamoto, Hidetaka

AU - Oda, Yoshinao

AU - Endo, Makoto

AU - Bekki, Hirofumi

AU - Matsunobu, Tomoya

AU - Nakashima, Yasuharu

AU - Okazaki, Ken

AU - Fukushi, Jun Ichi

AU - Oyamada, Akiko

AU - Iwamoto, Yukihide

PY - 2017

Y1 - 2017

N2 - Case: A patient with rheumatoid arthritis (RA) who was being treated with methotrexate (MTX) therapy presented with severe swelling of the left elbow. Magnetic resonance imaging showed a tumor-like lesion around the elbow joint. Fluorodeoxyglucose positron emission tomography indicated multiple lesions in the lung and the lymph nodes. An open biopsy of a cervical lymph node was performed, and MTX-related lymphoproliferative disorder (MTX-LPD) was diagnosed. After cessation of the MTX therapy, the elbow swelling regressed, and the patient was in remission of MTX-LPD. Conclusion: MTX-LPD should be considered in the differential diagnosis when a patient with RA develops severe joint swelling while on MTX therapy.

AB - Case: A patient with rheumatoid arthritis (RA) who was being treated with methotrexate (MTX) therapy presented with severe swelling of the left elbow. Magnetic resonance imaging showed a tumor-like lesion around the elbow joint. Fluorodeoxyglucose positron emission tomography indicated multiple lesions in the lung and the lymph nodes. An open biopsy of a cervical lymph node was performed, and MTX-related lymphoproliferative disorder (MTX-LPD) was diagnosed. After cessation of the MTX therapy, the elbow swelling regressed, and the patient was in remission of MTX-LPD. Conclusion: MTX-LPD should be considered in the differential diagnosis when a patient with RA develops severe joint swelling while on MTX therapy.

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U2 - 10.2106/JBJS.CC.17.00002

DO - 10.2106/JBJS.CC.17.00002

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SN - 2160-3251

VL - 7

JO - JBJS Case Connector

JF - JBJS Case Connector

IS - 3

M1 - e65

ER -

Methotrexate-related lymphoproliferative disorder presenting with severe swelling of the elbow joint

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