Methotrexate-related lymphoproliferative disorder presenting with severe swelling of the elbow joint

Takashi Hatano, Masanobu Ohishi, Goichi Yoshimoto, Moriyasu Yamauchi, Akira Maekawa, Hidetaka Yamamoto, Yoshinao Oda, Makoto Endo, Hirofumi Bekki, Tomoya Matsunobu, Yasuharu Nakashima, Ken Okazaki, Jun-Ichi Fukushi, Akiko Oyamada, Yukihide Iwamoto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Case: A patient with rheumatoid arthritis (RA) who was being treated with methotrexate (MTX) therapy presented with severe swelling of the left elbow. Magnetic resonance imaging showed a tumor-like lesion around the elbow joint. Fluorodeoxyglucose positron emission tomography indicated multiple lesions in the lung and the lymph nodes. An open biopsy of a cervical lymph node was performed, and MTX-related lymphoproliferative disorder (MTX-LPD) was diagnosed. After cessation of the MTX therapy, the elbow swelling regressed, and the patient was in remission of MTX-LPD. Conclusion: MTX-LPD should be considered in the differential diagnosis when a patient with RA develops severe joint swelling while on MTX therapy.

Original languageEnglish
Article numbere65
JournalJBJS Case Connector
Volume7
Issue number3
DOIs
Publication statusPublished - Jan 1 2017

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Elbow Joint
Lymphoproliferative Disorders
Methotrexate
Elbow
Rheumatoid Arthritis
Lymph Nodes
Positron-Emission Tomography
Differential Diagnosis
Therapeutics
Joints
Magnetic Resonance Imaging
Biopsy
Lung
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Methotrexate-related lymphoproliferative disorder presenting with severe swelling of the elbow joint. / Hatano, Takashi; Ohishi, Masanobu; Yoshimoto, Goichi; Yamauchi, Moriyasu; Maekawa, Akira; Yamamoto, Hidetaka; Oda, Yoshinao; Endo, Makoto; Bekki, Hirofumi; Matsunobu, Tomoya; Nakashima, Yasuharu; Okazaki, Ken; Fukushi, Jun-Ichi; Oyamada, Akiko; Iwamoto, Yukihide.

In: JBJS Case Connector, Vol. 7, No. 3, e65, 01.01.2017.

Research output: Contribution to journalArticle

Hatano, T, Ohishi, M, Yoshimoto, G, Yamauchi, M, Maekawa, A, Yamamoto, H, Oda, Y, Endo, M, Bekki, H, Matsunobu, T, Nakashima, Y, Okazaki, K, Fukushi, J-I, Oyamada, A & Iwamoto, Y 2017, 'Methotrexate-related lymphoproliferative disorder presenting with severe swelling of the elbow joint', JBJS Case Connector, vol. 7, no. 3, e65. https://doi.org/10.2106/JBJS.CC.17.00002
Hatano, Takashi ; Ohishi, Masanobu ; Yoshimoto, Goichi ; Yamauchi, Moriyasu ; Maekawa, Akira ; Yamamoto, Hidetaka ; Oda, Yoshinao ; Endo, Makoto ; Bekki, Hirofumi ; Matsunobu, Tomoya ; Nakashima, Yasuharu ; Okazaki, Ken ; Fukushi, Jun-Ichi ; Oyamada, Akiko ; Iwamoto, Yukihide. / Methotrexate-related lymphoproliferative disorder presenting with severe swelling of the elbow joint. In: JBJS Case Connector. 2017 ; Vol. 7, No. 3.
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AU - Hatano, Takashi

AU - Ohishi, Masanobu

AU - Yoshimoto, Goichi

AU - Yamauchi, Moriyasu

AU - Maekawa, Akira

AU - Yamamoto, Hidetaka

AU - Oda, Yoshinao

AU - Endo, Makoto

AU - Bekki, Hirofumi

AU - Matsunobu, Tomoya

AU - Nakashima, Yasuharu

AU - Okazaki, Ken

AU - Fukushi, Jun-Ichi

AU - Oyamada, Akiko

AU - Iwamoto, Yukihide

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