TY - JOUR
T1 - Methylation of drug resistance-related genes in chemotherapy-sensitive Epstein–Barr virus-associated gastric cancer
AU - Ohmura, Hirofumi
AU - Ito, Mamoru
AU - Uchino, Keita
AU - Okada, Chihiro
AU - Tanishima, Shigeki
AU - Yamada, Yuichi
AU - Momosaki, Seiya
AU - Komoda, Masato
AU - Kuwayama, Miyuki
AU - Yamaguchi, Kyoko
AU - Okumura, Yuta
AU - Nakano, Michitaka
AU - Tsuchihashi, Kenji
AU - Isobe, Taichi
AU - Ariyama, Hiroshi
AU - Kusaba, Hitoshi
AU - Oda, Yoshinao
AU - Akashi, Koichi
AU - Baba, Eishi
N1 - Funding Information:
EB and KT received honoraria from Taiho Pharma. KA received research funding from Taiho Pharma. The remaining authors declare no conflict of interest.
Publisher Copyright:
© 2019 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Epstein–Barr virus (EBV)-associated gastric cancer (GC) is associated with a high degree of DNA methylation. However, the association between chemotherapy susceptibility and tumor DNA methylation in advanced diseases remains unclear. The comprehensive DNA methylation status of GC cells obtained from an advanced EBV-associated GC (EBVGC) case, in which complete response to S-1 plus cisplatin chemotherapy was achieved, was analyzed using a DNA methylation microarray. We compared DNA methylation of GC cells with public data and identified genes with higher methylation in EBVGC cell lines than in normal gastric cells, and genes in which methylation was increased by EBV. Of these genes, ABCG2, AHNAK2, BCL2, FZD1, and TP73 are associated with published evidence for resistance to 5-fluorouracil and cisplatin. Silencing of these genes may be associated with hypersensitivity to chemotherapy.
AB - Epstein–Barr virus (EBV)-associated gastric cancer (GC) is associated with a high degree of DNA methylation. However, the association between chemotherapy susceptibility and tumor DNA methylation in advanced diseases remains unclear. The comprehensive DNA methylation status of GC cells obtained from an advanced EBV-associated GC (EBVGC) case, in which complete response to S-1 plus cisplatin chemotherapy was achieved, was analyzed using a DNA methylation microarray. We compared DNA methylation of GC cells with public data and identified genes with higher methylation in EBVGC cell lines than in normal gastric cells, and genes in which methylation was increased by EBV. Of these genes, ABCG2, AHNAK2, BCL2, FZD1, and TP73 are associated with published evidence for resistance to 5-fluorouracil and cisplatin. Silencing of these genes may be associated with hypersensitivity to chemotherapy.
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U2 - 10.1002/2211-5463.12765
DO - 10.1002/2211-5463.12765
M3 - Article
C2 - 31736281
AN - SCOPUS:85076136283
VL - 10
SP - 147
EP - 157
JO - FEBS Open Bio
JF - FEBS Open Bio
SN - 2211-5463
IS - 1
ER -
