Mexiletine reverses Oxaliplatin-Induced neuropathic pain in rats

Nobuaki Egashira, Shingo Hirakawa, Takehiro Kawashiri, Takahisa Yano, Hiroaki Ikesue, Ryozo Oishi

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Oxaliplatin is a platinum-based chemotherapy drug characterized by the development of acute and chronic peripheral neuropathies. Mexiletine, an orally available Na+-channel blocker, has widely been used in patients with chronic painful diabetic neuropathy. In the present study, we examined the effect of mexiletine on oxaliplatin-induced neuropathic pain in rats. Mexiletine (100, but not 10 and 30, mg/kg, p.o.) completely reversed both mechanical allodynia and cold hyperalgesia induced by oxaliplatin (4 mg/kg, i.p., twice a week). Lidocaine (30, but not 3 and 10, mg/kg, i.p.) also significantly relieved both pain behaviors. These results suggest that mexiletine may be effective in relieving the oxaliplatin-induced neuropathic pain clinically.

Original languageEnglish
Pages (from-to)473-476
Number of pages4
JournalJournal of Pharmacological Sciences
Volume112
Issue number4
DOIs
Publication statusPublished - Apr 16 2010

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oxaliplatin
Mexiletine
Neuralgia
Hyperalgesia
Diabetic Neuropathies
Peripheral Nervous System Diseases
Lidocaine
Platinum
Drug Therapy
Pain

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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Mexiletine reverses Oxaliplatin-Induced neuropathic pain in rats. / Egashira, Nobuaki; Hirakawa, Shingo; Kawashiri, Takehiro; Yano, Takahisa; Ikesue, Hiroaki; Oishi, Ryozo.

In: Journal of Pharmacological Sciences, Vol. 112, No. 4, 16.04.2010, p. 473-476.

Research output: Contribution to journalArticle

Egashira, Nobuaki ; Hirakawa, Shingo ; Kawashiri, Takehiro ; Yano, Takahisa ; Ikesue, Hiroaki ; Oishi, Ryozo. / Mexiletine reverses Oxaliplatin-Induced neuropathic pain in rats. In: Journal of Pharmacological Sciences. 2010 ; Vol. 112, No. 4. pp. 473-476.
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