Mexiletine reverses Oxaliplatin-Induced neuropathic pain in rats

Nobuaki Egashira, Shingo Hirakawa, Takehiro Kawashiri, Takahisa Yano, Hiroaki Ikesue, Ryozo Oishi

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Oxaliplatin is a platinum-based chemotherapy drug characterized by the development of acute and chronic peripheral neuropathies. Mexiletine, an orally available Na+-channel blocker, has widely been used in patients with chronic painful diabetic neuropathy. In the present study, we examined the effect of mexiletine on oxaliplatin-induced neuropathic pain in rats. Mexiletine (100, but not 10 and 30, mg/kg, p.o.) completely reversed both mechanical allodynia and cold hyperalgesia induced by oxaliplatin (4 mg/kg, i.p., twice a week). Lidocaine (30, but not 3 and 10, mg/kg, i.p.) also significantly relieved both pain behaviors. These results suggest that mexiletine may be effective in relieving the oxaliplatin-induced neuropathic pain clinically.

Original languageEnglish
Pages (from-to)473-476
Number of pages4
JournalJournal of Pharmacological Sciences
Volume112
Issue number4
DOIs
Publication statusPublished - Apr 16 2010

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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