MFG-E8-dependent clearance of apoptotic cells, and autoimmunity caused by its failure.

Rikinari Hanayama, Kay Miyasaka, Michio Nakaya, Shigekazu Nagata

Research output: Contribution to journalReview articlepeer-review

50 Citations (Scopus)


Apoptotic cells are swiftly engulfed by macrophages and immature dendritic cells. Inefficient clearance of apoptotic cells has been implicated as a cause of inflammation and autoimmune diseases. Milk fat globule-EGF factor 8 (MFG-E8) and developmental endothelial locus-1 (Del-1) are glycoproteins secreted from macrophages that pass apoptotic cells to phagocytes. MFG-E8, but not Del-1, is expressed in the tingible-body macrophages at the germinal centers of the second lymphoid tissues. MFG-E8-deficient mice carry many unengulfed apoptotic cells in the germinal centers of the spleen, and develop a lupus-like autoimmune disease. In this review, we discuss the importance of the MFG-E8-mediated clearance of apoptotic cells in the prevention of autoimmune diseases.

Original languageEnglish
Pages (from-to)162-172
Number of pages11
JournalCurrent directions in autoimmunity
Publication statusPublished - 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)


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