MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line

Christopher J. Savoie, Nobuhiro Kamikawaji, Tohru Sudo, Masanori Furuse, Senji Shirasawa, Takeshi Tana, Takehiko Sasazuki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

MHC class I associated peptides on cancer cells represent potential targets for CD8+ cytotoxic T cell activity against tumor cells. We eluted the naturally bound MHC class I peptides of a colon carcinoma cell line and compared them to peptides isolated from a B cell line and a slow-growing activated Ki-ras-disrupted colon cancer cell line. While we failed to detect any significant differences in class I associated peptides due to the presence or absence of activated Ki-ras in colon cancer cell lines, the colon cancer cell lines and B cell line presented vastly different peptide repertoires in the context of HLA-A*0201 molecules.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalCancer Letters
Volume123
Issue number2
DOIs
Publication statusPublished - Jan 30 1998

Fingerprint

ras Genes
Colon
B-Lymphocytes
Carcinoma
Cell Line
Peptides
Colonic Neoplasms
Neoplasms
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Savoie, C. J., Kamikawaji, N., Sudo, T., Furuse, M., Shirasawa, S., Tana, T., & Sasazuki, T. (1998). MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line. Cancer Letters, 123(2), 193-197. https://doi.org/10.1016/S0304-3835(97)00418-7

MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line. / Savoie, Christopher J.; Kamikawaji, Nobuhiro; Sudo, Tohru; Furuse, Masanori; Shirasawa, Senji; Tana, Takeshi; Sasazuki, Takehiko.

In: Cancer Letters, Vol. 123, No. 2, 30.01.1998, p. 193-197.

Research output: Contribution to journalArticle

Savoie, CJ, Kamikawaji, N, Sudo, T, Furuse, M, Shirasawa, S, Tana, T & Sasazuki, T 1998, 'MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line', Cancer Letters, vol. 123, no. 2, pp. 193-197. https://doi.org/10.1016/S0304-3835(97)00418-7
Savoie, Christopher J. ; Kamikawaji, Nobuhiro ; Sudo, Tohru ; Furuse, Masanori ; Shirasawa, Senji ; Tana, Takeshi ; Sasazuki, Takehiko. / MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line. In: Cancer Letters. 1998 ; Vol. 123, No. 2. pp. 193-197.
@article{5263001969c34e7eb030c18b58ece736,
title = "MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line",
abstract = "MHC class I associated peptides on cancer cells represent potential targets for CD8+ cytotoxic T cell activity against tumor cells. We eluted the naturally bound MHC class I peptides of a colon carcinoma cell line and compared them to peptides isolated from a B cell line and a slow-growing activated Ki-ras-disrupted colon cancer cell line. While we failed to detect any significant differences in class I associated peptides due to the presence or absence of activated Ki-ras in colon cancer cell lines, the colon cancer cell lines and B cell line presented vastly different peptide repertoires in the context of HLA-A*0201 molecules.",
author = "Savoie, {Christopher J.} and Nobuhiro Kamikawaji and Tohru Sudo and Masanori Furuse and Senji Shirasawa and Takeshi Tana and Takehiko Sasazuki",
year = "1998",
month = "1",
day = "30",
doi = "10.1016/S0304-3835(97)00418-7",
language = "English",
volume = "123",
pages = "193--197",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line

AU - Savoie, Christopher J.

AU - Kamikawaji, Nobuhiro

AU - Sudo, Tohru

AU - Furuse, Masanori

AU - Shirasawa, Senji

AU - Tana, Takeshi

AU - Sasazuki, Takehiko

PY - 1998/1/30

Y1 - 1998/1/30

N2 - MHC class I associated peptides on cancer cells represent potential targets for CD8+ cytotoxic T cell activity against tumor cells. We eluted the naturally bound MHC class I peptides of a colon carcinoma cell line and compared them to peptides isolated from a B cell line and a slow-growing activated Ki-ras-disrupted colon cancer cell line. While we failed to detect any significant differences in class I associated peptides due to the presence or absence of activated Ki-ras in colon cancer cell lines, the colon cancer cell lines and B cell line presented vastly different peptide repertoires in the context of HLA-A*0201 molecules.

AB - MHC class I associated peptides on cancer cells represent potential targets for CD8+ cytotoxic T cell activity against tumor cells. We eluted the naturally bound MHC class I peptides of a colon carcinoma cell line and compared them to peptides isolated from a B cell line and a slow-growing activated Ki-ras-disrupted colon cancer cell line. While we failed to detect any significant differences in class I associated peptides due to the presence or absence of activated Ki-ras in colon cancer cell lines, the colon cancer cell lines and B cell line presented vastly different peptide repertoires in the context of HLA-A*0201 molecules.

UR - http://www.scopus.com/inward/record.url?scp=0032579185&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032579185&partnerID=8YFLogxK

U2 - 10.1016/S0304-3835(97)00418-7

DO - 10.1016/S0304-3835(97)00418-7

M3 - Article

C2 - 9489488

AN - SCOPUS:0032579185

VL - 123

SP - 193

EP - 197

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 2

ER -