MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line

Christopher J. Savoie; Nobuhiro Kamikawaji; Tohru Sudo; Masanori Furuse; Senji Shirasawa; Takeshi Tana; Takehiko Sasazuki

doi:10.1016/S0304-3835(97)00418-7

MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line

Christopher J. Savoie, Nobuhiro Kamikawaji, Tohru Sudo, Masanori Furuse, Senji Shirasawa, Takeshi Tana, Takehiko Sasazuki

Institute for Advanced Study

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

MHC class I associated peptides on cancer cells represent potential targets for CD8⁺ cytotoxic T cell activity against tumor cells. We eluted the naturally bound MHC class I peptides of a colon carcinoma cell line and compared them to peptides isolated from a B cell line and a slow-growing activated Ki-ras-disrupted colon cancer cell line. While we failed to detect any significant differences in class I associated peptides due to the presence or absence of activated Ki-ras in colon cancer cell lines, the colon cancer cell lines and B cell line presented vastly different peptide repertoires in the context of HLA-A*0201 molecules.

Original language	English
Pages (from-to)	193-197
Number of pages	5
Journal	Cancer Letters
Volume	123
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(97)00418-7
Publication status	Published - Jan 30 1998

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(97)00418-7

Cite this

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title = "MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line",

abstract = "MHC class I associated peptides on cancer cells represent potential targets for CD8+ cytotoxic T cell activity against tumor cells. We eluted the naturally bound MHC class I peptides of a colon carcinoma cell line and compared them to peptides isolated from a B cell line and a slow-growing activated Ki-ras-disrupted colon cancer cell line. While we failed to detect any significant differences in class I associated peptides due to the presence or absence of activated Ki-ras in colon cancer cell lines, the colon cancer cell lines and B cell line presented vastly different peptide repertoires in the context of HLA-A*0201 molecules.",

author = "Savoie, {Christopher J.} and Nobuhiro Kamikawaji and Tohru Sudo and Masanori Furuse and Senji Shirasawa and Takeshi Tana and Takehiko Sasazuki",

note = "Funding Information: This work was supported by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science, Sports and Culture and research grants from the Ministry of Health and Welfare of Japan.",

year = "1998",

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doi = "10.1016/S0304-3835(97)00418-7",

language = "English",

volume = "123",

pages = "193--197",

journal = "Cancer Letters",

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TY - JOUR

T1 - MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line

AU - Savoie, Christopher J.

AU - Kamikawaji, Nobuhiro

AU - Sudo, Tohru

AU - Furuse, Masanori

AU - Shirasawa, Senji

AU - Tana, Takeshi

AU - Sasazuki, Takehiko

N1 - Funding Information: This work was supported by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science, Sports and Culture and research grants from the Ministry of Health and Welfare of Japan.

PY - 1998/1/30

Y1 - 1998/1/30

N2 - MHC class I associated peptides on cancer cells represent potential targets for CD8+ cytotoxic T cell activity against tumor cells. We eluted the naturally bound MHC class I peptides of a colon carcinoma cell line and compared them to peptides isolated from a B cell line and a slow-growing activated Ki-ras-disrupted colon cancer cell line. While we failed to detect any significant differences in class I associated peptides due to the presence or absence of activated Ki-ras in colon cancer cell lines, the colon cancer cell lines and B cell line presented vastly different peptide repertoires in the context of HLA-A*0201 molecules.

AB - MHC class I associated peptides on cancer cells represent potential targets for CD8+ cytotoxic T cell activity against tumor cells. We eluted the naturally bound MHC class I peptides of a colon carcinoma cell line and compared them to peptides isolated from a B cell line and a slow-growing activated Ki-ras-disrupted colon cancer cell line. While we failed to detect any significant differences in class I associated peptides due to the presence or absence of activated Ki-ras in colon cancer cell lines, the colon cancer cell lines and B cell line presented vastly different peptide repertoires in the context of HLA-A*0201 molecules.

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U2 - 10.1016/S0304-3835(97)00418-7

DO - 10.1016/S0304-3835(97)00418-7

M3 - Article

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AN - SCOPUS:0032579185

VL - 123

SP - 193

EP - 197

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 2

ER -

MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line

Abstract

All Science Journal Classification (ASJC) codes

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