Abstract
MHC class I associated peptides on cancer cells represent potential targets for CD8+ cytotoxic T cell activity against tumor cells. We eluted the naturally bound MHC class I peptides of a colon carcinoma cell line and compared them to peptides isolated from a B cell line and a slow-growing activated Ki-ras-disrupted colon cancer cell line. While we failed to detect any significant differences in class I associated peptides due to the presence or absence of activated Ki-ras in colon cancer cell lines, the colon cancer cell lines and B cell line presented vastly different peptide repertoires in the context of HLA-A*0201 molecules.
| Original language | English |
|---|---|
| Pages (from-to) | 193-197 |
| Number of pages | 5 |
| Journal | Cancer Letters |
| Volume | 123 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 30 1998 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
Cite this
MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line. / Savoie, Christopher J.; Kamikawaji, Nobuhiro; Sudo, Tohru; Furuse, Masanori; Shirasawa, Senji; Tana, Takeshi; Sasazuki, Takehiko.
In: Cancer Letters, Vol. 123, No. 2, 30.01.1998, p. 193-197.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line
AU - Savoie, Christopher J.
AU - Kamikawaji, Nobuhiro
AU - Sudo, Tohru
AU - Furuse, Masanori
AU - Shirasawa, Senji
AU - Tana, Takeshi
AU - Sasazuki, Takehiko
PY - 1998/1/30
Y1 - 1998/1/30
N2 - MHC class I associated peptides on cancer cells represent potential targets for CD8+ cytotoxic T cell activity against tumor cells. We eluted the naturally bound MHC class I peptides of a colon carcinoma cell line and compared them to peptides isolated from a B cell line and a slow-growing activated Ki-ras-disrupted colon cancer cell line. While we failed to detect any significant differences in class I associated peptides due to the presence or absence of activated Ki-ras in colon cancer cell lines, the colon cancer cell lines and B cell line presented vastly different peptide repertoires in the context of HLA-A*0201 molecules.
AB - MHC class I associated peptides on cancer cells represent potential targets for CD8+ cytotoxic T cell activity against tumor cells. We eluted the naturally bound MHC class I peptides of a colon carcinoma cell line and compared them to peptides isolated from a B cell line and a slow-growing activated Ki-ras-disrupted colon cancer cell line. While we failed to detect any significant differences in class I associated peptides due to the presence or absence of activated Ki-ras in colon cancer cell lines, the colon cancer cell lines and B cell line presented vastly different peptide repertoires in the context of HLA-A*0201 molecules.
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UR - http://www.scopus.com/inward/citedby.url?scp=0032579185&partnerID=8YFLogxK
U2 - 10.1016/S0304-3835(97)00418-7
DO - 10.1016/S0304-3835(97)00418-7
M3 - Article
C2 - 9489488
AN - SCOPUS:0032579185
VL - 123
SP - 193
EP - 197
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 2
ER -