MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line

Christopher J. Savoie, Nobuhiro Kamikawaji, Tohru Sudo, Masanori Furuse, Senji Shirasawa, Takeshi Tana, Takehiko Sasazuki

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

MHC class I associated peptides on cancer cells represent potential targets for CD8+ cytotoxic T cell activity against tumor cells. We eluted the naturally bound MHC class I peptides of a colon carcinoma cell line and compared them to peptides isolated from a B cell line and a slow-growing activated Ki-ras-disrupted colon cancer cell line. While we failed to detect any significant differences in class I associated peptides due to the presence or absence of activated Ki-ras in colon cancer cell lines, the colon cancer cell lines and B cell line presented vastly different peptide repertoires in the context of HLA-A*0201 molecules.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalCancer Letters
Volume123
Issue number2
DOIs
Publication statusPublished - Jan 30 1998

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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