Mice deficient in Dmrt7 show infertility with spermatogenic arrest at pachytene stage

Masaki Kawamata, Katsuhiko Nishimori

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Genes including DM domain regulate sexual development in diverse metazoan phyla. One of these genes, Dmrt7, was expressed only in testes of adult mice. To determine the role of Dmrt7 in mice, we generated Dmrt7-knockout mice (Dmrt7-/-). Although the Dmrt7-/- showed normal growth, null males were infertile. No sperm was detected in the epididymis of Dmrt7-/- adult males. Absence of spermatids in a histological analysis, decreased expression of Ccna1 mRNA and the accumulation of SCP3-positive spermatocytes showed the arrest of spermatogenesis at the pachytene stage in the Dmrt7-knockout mice.

Original languageEnglish
Pages (from-to)6442-6446
Number of pages5
JournalFEBS Letters
Volume580
Issue number27
DOIs
Publication statusPublished - Nov 27 2006

Fingerprint

Pachytene Stage
Knockout Mice
Infertility
Genes
Messenger RNA
Sexual Development
Spermatocytes
Spermatids
Epididymis
Spermatozoa
Testis
Growth

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Mice deficient in Dmrt7 show infertility with spermatogenic arrest at pachytene stage. / Kawamata, Masaki; Nishimori, Katsuhiko.

In: FEBS Letters, Vol. 580, No. 27, 27.11.2006, p. 6442-6446.

Research output: Contribution to journalArticle

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