Interleukin-2 (IL-2)/IL-15 receptor β (IL-15Rβ)-/- mice were susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis, whereas IL-2-/- mice were resistant. A natural killer cell response was not evident for both types of deficient mice. A Th1 response was detected in IL-2-/- but not in IL-2/IL-15Rβ-/- mice infected with Salmonella, suggesting that IL-2/IL-15Rβ signaling is important for the generation of protective Th1 cells.
All Science Journal Classification (ASJC) codes
- Infectious Diseases