Mice lacking interleukin-2 (IL-2)/IL-15 receptor β chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis but mice lacking IL-2 are resistant

H. Nishimura, M. Tagaya, H. Tsunobuchi, H. Suzuki, I. Nakashima, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Interleukin-2 (IL-2)/IL-15 receptor β (IL-15Rβ)-/- mice were susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis, whereas IL-2-/- mice were resistant. A natural killer cell response was not evident for both types of deficient mice. A Th1 response was detected in IL-2-/- but not in IL-2/IL-15Rβ-/- mice infected with Salmonella, suggesting that IL-2/IL-15Rβ signaling is important for the generation of protective Th1 cells.

    Original languageEnglish
    Pages (from-to)1226-1229
    Number of pages4
    JournalInfection and Immunity
    Volume69
    Issue number2
    DOIs
    Publication statusPublished - Feb 12 2001

    Fingerprint

    Interleukin-15 Receptors
    Salmonella enterica
    Interleukin-2
    Infection
    Th1 Cells
    Salmonella
    Natural Killer Cells
    Serogroup

    All Science Journal Classification (ASJC) codes

    • Parasitology
    • Microbiology
    • Immunology
    • Infectious Diseases

    Cite this

    Mice lacking interleukin-2 (IL-2)/IL-15 receptor β chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis but mice lacking IL-2 are resistant. / Nishimura, H.; Tagaya, M.; Tsunobuchi, H.; Suzuki, H.; Nakashima, I.; Yoshikai, Yasunobu.

    In: Infection and Immunity, Vol. 69, No. 2, 12.02.2001, p. 1226-1229.

    Research output: Contribution to journalArticle

    @article{4d26f6e752f14a77953f3fcd4086db54,
    title = "Mice lacking interleukin-2 (IL-2)/IL-15 receptor β chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis but mice lacking IL-2 are resistant",
    abstract = "Interleukin-2 (IL-2)/IL-15 receptor β (IL-15Rβ)-/- mice were susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis, whereas IL-2-/- mice were resistant. A natural killer cell response was not evident for both types of deficient mice. A Th1 response was detected in IL-2-/- but not in IL-2/IL-15Rβ-/- mice infected with Salmonella, suggesting that IL-2/IL-15Rβ signaling is important for the generation of protective Th1 cells.",
    author = "H. Nishimura and M. Tagaya and H. Tsunobuchi and H. Suzuki and I. Nakashima and Yasunobu Yoshikai",
    year = "2001",
    month = "2",
    day = "12",
    doi = "10.1128/IAI.69.2.1226-1229.2001",
    language = "English",
    volume = "69",
    pages = "1226--1229",
    journal = "Infection and Immunity",
    issn = "0019-9567",
    publisher = "American Society for Microbiology",
    number = "2",

    }

    TY - JOUR

    T1 - Mice lacking interleukin-2 (IL-2)/IL-15 receptor β chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis but mice lacking IL-2 are resistant

    AU - Nishimura, H.

    AU - Tagaya, M.

    AU - Tsunobuchi, H.

    AU - Suzuki, H.

    AU - Nakashima, I.

    AU - Yoshikai, Yasunobu

    PY - 2001/2/12

    Y1 - 2001/2/12

    N2 - Interleukin-2 (IL-2)/IL-15 receptor β (IL-15Rβ)-/- mice were susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis, whereas IL-2-/- mice were resistant. A natural killer cell response was not evident for both types of deficient mice. A Th1 response was detected in IL-2-/- but not in IL-2/IL-15Rβ-/- mice infected with Salmonella, suggesting that IL-2/IL-15Rβ signaling is important for the generation of protective Th1 cells.

    AB - Interleukin-2 (IL-2)/IL-15 receptor β (IL-15Rβ)-/- mice were susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis, whereas IL-2-/- mice were resistant. A natural killer cell response was not evident for both types of deficient mice. A Th1 response was detected in IL-2-/- but not in IL-2/IL-15Rβ-/- mice infected with Salmonella, suggesting that IL-2/IL-15Rβ signaling is important for the generation of protective Th1 cells.

    UR - http://www.scopus.com/inward/record.url?scp=0035142107&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0035142107&partnerID=8YFLogxK

    U2 - 10.1128/IAI.69.2.1226-1229.2001

    DO - 10.1128/IAI.69.2.1226-1229.2001

    M3 - Article

    VL - 69

    SP - 1226

    EP - 1229

    JO - Infection and Immunity

    JF - Infection and Immunity

    SN - 0019-9567

    IS - 2

    ER -