Mice lacking interleukin-2 (IL-2)/IL-15 receptor β chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis but mice lacking IL-2 are resistant

H. Nishimura, M. Tagaya, H. Tsunobuchi, H. Suzuki, I. Nakashima, Y. Yoshikai

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Interleukin-2 (IL-2)/IL-15 receptor β (IL-15Rβ)-/- mice were susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis, whereas IL-2-/- mice were resistant. A natural killer cell response was not evident for both types of deficient mice. A Th1 response was detected in IL-2-/- but not in IL-2/IL-15Rβ-/- mice infected with Salmonella, suggesting that IL-2/IL-15Rβ signaling is important for the generation of protective Th1 cells.

    Original languageEnglish
    Pages (from-to)1226-1229
    Number of pages4
    JournalInfection and Immunity
    Volume69
    Issue number2
    DOIs
    Publication statusPublished - 2001

    All Science Journal Classification (ASJC) codes

    • Parasitology
    • Microbiology
    • Immunology
    • Infectious Diseases

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