Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system

R. L. Schnaar, A. Yamamoto, K. Furukawa, S. Yamashiro, M. Shin, M. Okada, S. Fukumoto, M. Haraguchi, N. Takeda, K. Fujimura, M. Sakae, M. Kishikawa, H. Shiku, K. Furukawa, S. Aizawa

Research output: Contribution to journalReview article

Abstract

Mice genetically engineered to lack complex brain gangliosides developed normal brain anatomy, histology, and ultrastructure, although they demonstrated a modest change in central nervous system conduction velocity.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalChemtracts
Volume11
Issue number3
Publication statusPublished - Mar 1 1998
Externally publishedYes

Fingerprint

(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase
Gangliosides
Neurology
Nervous System
Brain
Genes
Defects
Histology
Anatomy
Central Nervous System

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry
  • Molecular Biology

Cite this

Schnaar, R. L., Yamamoto, A., Furukawa, K., Yamashiro, S., Shin, M., Okada, M., ... Aizawa, S. (1998). Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system. Chemtracts, 11(3), 195-200.

Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system. / Schnaar, R. L.; Yamamoto, A.; Furukawa, K.; Yamashiro, S.; Shin, M.; Okada, M.; Fukumoto, S.; Haraguchi, M.; Takeda, N.; Fujimura, K.; Sakae, M.; Kishikawa, M.; Shiku, H.; Furukawa, K.; Aizawa, S.

In: Chemtracts, Vol. 11, No. 3, 01.03.1998, p. 195-200.

Research output: Contribution to journalReview article

Schnaar, RL, Yamamoto, A, Furukawa, K, Yamashiro, S, Shin, M, Okada, M, Fukumoto, S, Haraguchi, M, Takeda, N, Fujimura, K, Sakae, M, Kishikawa, M, Shiku, H, Furukawa, K & Aizawa, S 1998, 'Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system', Chemtracts, vol. 11, no. 3, pp. 195-200.
Schnaar RL, Yamamoto A, Furukawa K, Yamashiro S, Shin M, Okada M et al. Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system. Chemtracts. 1998 Mar 1;11(3):195-200.
Schnaar, R. L. ; Yamamoto, A. ; Furukawa, K. ; Yamashiro, S. ; Shin, M. ; Okada, M. ; Fukumoto, S. ; Haraguchi, M. ; Takeda, N. ; Fujimura, K. ; Sakae, M. ; Kishikawa, M. ; Shiku, H. ; Furukawa, K. ; Aizawa, S. / Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system. In: Chemtracts. 1998 ; Vol. 11, No. 3. pp. 195-200.
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