Micelles consisting of choline phosphate-bearing Calix[4]arene lipids

Shota Fujii, Koichi Nishina, Shimpei Yamada, Shinichi Mochizuki, Noboru Ohta, Atsushi Takahara, Kazuo Sakurai

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

We synthesized new calix[4]arene-based lipids, denoted by CPCaLn, bearing the choline phosphate (CP) group which is an inverse phosphoryl choline (PC) structure. Small-angle X-ray scattering and multi-angle light scattering coupled with field flow fractionation showed that these lipids form monodisperse micelles with a fixed aggregation number and diameters of 1.9 and 2.6 nm for lipids bearing C3 and C6 alkyl tails, respectively. Furthermore, when CPCaLn was mixed with the fluorescein isothiocyanate (FITC)-bearing lipids and added to cells, strong fluorescence was observed at 37 °C, but not at 4°C, indicating that the micelles were taken up by the cells through endocytosis. Recent studies have shown that replacement of polymer-attached PC groups with CP groups markedly promotes cellular uptake, even though the surface charge is neutral. On the basis of the idea, CPCaLn micelles interacted with cells in the same way, suggesting that the micelles bearing CP groups are expected to use as carriers in the drug delivery system. This journal is

Original languageEnglish
Pages (from-to)8216-8223
Number of pages8
JournalSoft Matter
Volume10
Issue number41
DOIs
Publication statusPublished - Nov 7 2014

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Micelles consisting of choline phosphate-bearing Calix[4]arene lipids'. Together they form a unique fingerprint.

Cite this