Microarray analysis reveals that high mobility group A1 is involved in colorectal cancer metastasis

Yusuke Takahashi, Genta Sawada, Tetsuya Sato, Junji Kurashige, Kosuke Mima, Tae Matsumura, Ryutaro Uchi, Hiroki Ueo, Masahisa Ishibashi, Yuki Takano, Sayuri Akiyoshi, Hidetoshi Eguchi, Tomoya Sudo, Keishi Sugimachi, Jun Ichi Tanaka, Shin Ei Kudo, Yuichiro Doki, Masaki Mori, Koshi Mimori

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Tumor size indicates the extent of cell proliferation in most cases of colorectal cancer (CRC), although there are some advanced small tumors with metastases. Lymph node metastasis is a significant factor that greatly impacts disease prognosis in CRC cases. The underlying factors that cause lymph node metastasis in CRC cells are not fully understood. We investigated the mechanism that might induce CRC metastasis by focusing on smaller sized (<2 cm) invasive tumors. We carried out gene expression array analysis for CRC cases; group 1 consisted of 6 cases with tumors <2 cm with metastases, and group 2 consisted of 65 cases with tumors >2 cm without metastases. Results were validated using gene expression array data from an additional 77 cases and another bulk case set of 172 cases. Gene Ontology and pathway analysis using microarray data revealed that anti-apoptotic activity had a crucial role in CRC metastasis. High mobility group A1 (HMGA1) was identified as a biomarker for poor prognosis and metastasis formation. HMGA1 expression levels were higher in lymph node-positive cases than in lymph node-negative cases, even in subgroup analysis of submucosal invasive cases. The present study strongly supports the clinical significance of HMGA1 expression as a predictive indicator of lymph node metastasis in CRC cases, even in submucosal invasive cases which could be cured by local resection.

Original languageEnglish
Pages (from-to)1488-1496
Number of pages9
JournalOncology reports
Volume30
Issue number3
DOIs
Publication statusPublished - Sep 2013

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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