Microarray data on altered transcriptional program of Phgdh-deficient mouse embryonic fibroblasts caused by L-serine depletion

Momoko Hamano, Tomoko Sayano, Wataru Kusada, Hisanori Kato, Shigeki Furuya

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Inherent L-Ser deficiency culminates in intrauterine growth retardation, severe malformation of multiple organs particularly the central nervous system, and perinatal or early postnatal death in human and mouse. To uncover the molecular mechanisms underlying the growth-arrested phenotypes of l-Ser deficiency, we compared gene expression profiles of mouse embryonic fibroblasts deficient in 3-phosphoglycerate dehydrogenase (Phgdh), the first enzyme of de novo L-Ser synthetic pathway, between L-Ser-depleted and -supplemented conditions. The datasets (CEL and CHP files) from this study are publicly available on the Gene Expression Omnibus repository (accession number GEO: GSE55687).

Original languageEnglish
Pages (from-to)1598-1601
Number of pages4
JournalData in Brief
Volume7
DOIs
Publication statusPublished - Jun 1 2016

All Science Journal Classification (ASJC) codes

  • General

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