Microfabrication and microfluidic devices for drug delivery

Niko Kimura, Masatoshi Maeki, Manabu Tokeshi

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

Carrier-assist drug delivery systems (DDSs) have been developed to improve the present problems of the cancer chemotherapies. In the developed several types of DDS carriers, lipid nanoparticles (LNPs) are the most widely used for the cancer chemotherapy. Although LNPs have high biocompatibility and good circulation time in blood, precise size control of LNPs in the size range of 20-100 nm is required for the cancer therapy applications. Microfluidic devices will be key apparatus to achieve the size-controlled LNP synthesis. A microfluidic device with micromixer structures also plays important role for the LNP production, because it enables rapid mixing of lipid solution and aqueous solution for precise LNP size control. This chapter provides the microfluidic-based LNP production methods from the device fabrication to DDS applications.

Original languageEnglish
Title of host publicationMicrofluidics for Pharmaceutical Applications
Subtitle of host publicationFrom Nano/Micro Systems Fabrication to Controlled Drug Delivery
PublisherElsevier
Pages123-136
Number of pages14
ISBN (Electronic)9780128126592
ISBN (Print)9780128126608
DOIs
Publication statusPublished - Jan 1 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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