Carrier-assist drug delivery systems (DDSs) have been developed to improve the present problems of the cancer chemotherapies. In the developed several types of DDS carriers, lipid nanoparticles (LNPs) are the most widely used for the cancer chemotherapy. Although LNPs have high biocompatibility and good circulation time in blood, precise size control of LNPs in the size range of 20–100nm is required for the cancer therapy applications. Microfluidic devices will be key apparatus to achieve the size-controlled LNP synthesis. A microfluidic device with micromixer structures also plays important role for the LNP production, because it enables rapid mixing of lipid solution and aqueous solution for precise LNP size control. This chapter provides the microfluidic-based LNP production methods from the device fabrication to DDS applications.
|Title of host publication||Microfluidics for Pharmaceutical Applications|
|Subtitle of host publication||From Nano/Micro Systems Fabrication to Controlled Drug Delivery|
|Number of pages||14|
|Publication status||Published - Jan 1 2019|
All Science Journal Classification (ASJC) codes