Microfabrication and microfluidic devices for drug delivery

Niko Kimura; Masatoshi Maeki; Manabu Tokeshi

doi:10.1016/B978-0-12-812659-2.00005-3

Microfabrication and microfluidic devices for drug delivery

Niko Kimura, Masatoshi Maeki, Manabu Tokeshi

Research output: Chapter in Book/Report/Conference proceeding › Chapter

7 Citations (Scopus)

Abstract

Carrier-assist drug delivery systems (DDSs) have been developed to improve the present problems of the cancer chemotherapies. In the developed several types of DDS carriers, lipid nanoparticles (LNPs) are the most widely used for the cancer chemotherapy. Although LNPs have high biocompatibility and good circulation time in blood, precise size control of LNPs in the size range of 20–100nm is required for the cancer therapy applications. Microfluidic devices will be key apparatus to achieve the size-controlled LNP synthesis. A microfluidic device with micromixer structures also plays important role for the LNP production, because it enables rapid mixing of lipid solution and aqueous solution for precise LNP size control. This chapter provides the microfluidic-based LNP production methods from the device fabrication to DDS applications.

Original language	English
Title of host publication	Microfluidics for Pharmaceutical Applications
Subtitle of host publication	From Nano/Micro Systems Fabrication to Controlled Drug Delivery
Publisher	Elsevier
Pages	123-136
Number of pages	14
ISBN (Electronic)	9780128126592
ISBN (Print)	9780128126608
DOIs	https://doi.org/10.1016/B978-0-12-812659-2.00005-3
Publication status	Published - Jan 1 2019
Externally published	Yes

All Science Journal Classification (ASJC) codes

Chemistry(all)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-812659-2.00005-3

Cite this

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title = "Microfabrication and microfluidic devices for drug delivery",

abstract = "Carrier-assist drug delivery systems (DDSs) have been developed to improve the present problems of the cancer chemotherapies. In the developed several types of DDS carriers, lipid nanoparticles (LNPs) are the most widely used for the cancer chemotherapy. Although LNPs have high biocompatibility and good circulation time in blood, precise size control of LNPs in the size range of 20–100nm is required for the cancer therapy applications. Microfluidic devices will be key apparatus to achieve the size-controlled LNP synthesis. A microfluidic device with micromixer structures also plays important role for the LNP production, because it enables rapid mixing of lipid solution and aqueous solution for precise LNP size control. This chapter provides the microfluidic-based LNP production methods from the device fabrication to DDS applications.",

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AU - Kimura, Niko

AU - Maeki, Masatoshi

AU - Tokeshi, Manabu

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N2 - Carrier-assist drug delivery systems (DDSs) have been developed to improve the present problems of the cancer chemotherapies. In the developed several types of DDS carriers, lipid nanoparticles (LNPs) are the most widely used for the cancer chemotherapy. Although LNPs have high biocompatibility and good circulation time in blood, precise size control of LNPs in the size range of 20–100nm is required for the cancer therapy applications. Microfluidic devices will be key apparatus to achieve the size-controlled LNP synthesis. A microfluidic device with micromixer structures also plays important role for the LNP production, because it enables rapid mixing of lipid solution and aqueous solution for precise LNP size control. This chapter provides the microfluidic-based LNP production methods from the device fabrication to DDS applications.

AB - Carrier-assist drug delivery systems (DDSs) have been developed to improve the present problems of the cancer chemotherapies. In the developed several types of DDS carriers, lipid nanoparticles (LNPs) are the most widely used for the cancer chemotherapy. Although LNPs have high biocompatibility and good circulation time in blood, precise size control of LNPs in the size range of 20–100nm is required for the cancer therapy applications. Microfluidic devices will be key apparatus to achieve the size-controlled LNP synthesis. A microfluidic device with micromixer structures also plays important role for the LNP production, because it enables rapid mixing of lipid solution and aqueous solution for precise LNP size control. This chapter provides the microfluidic-based LNP production methods from the device fabrication to DDS applications.

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M3 - Chapter

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BT - Microfluidics for Pharmaceutical Applications

PB - Elsevier

ER -

Microfabrication and microfluidic devices for drug delivery

Abstract

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