Microfloral characterization of the tongue coating and associated risk for pneumonia-related health problems in institutionalized older adults

Toru Takeshita, Mikiko Tomioka, Yoshihiro Shimazaki, Miwa Matsuyama, Kiyoshi Koyano, Koichi Matsuda, Yoshihisa Yamashita

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objectives: To characterize a comprehensive outline of the oral microflora related to pneumonia in older adults. Design: Prospective and retrospective longitudinal study. Setting: Community. Participants: Long-term hospitalized patients and people in nursing homes (343 subjects, aged ≥65). Measurements: Subjects were assessed at baseline for pneumonia-related health problems. The flora of the tongue coating was characterized according to terminal restriction fragment length polymorphism (T-RFLP) analysis. All subjects were followed prospectively for 6 months for a diagnosis of pneumonia. The number of febrile days (>37.5°C) was assessed in 299 subjects who were observed for 12 months (retrospectively for 6 months and prospectively for 6 months). The follow-up data were analyzed using multivariate regression analyses in relation to the baseline data, including T-RFLP patterns. RESUTS: T-RFLP patterns outlining the floral composition of the tongue coating were grouped into Clusters A, B, C, and D. According to Cox regression analysis, the subjects in Clusters C (hazard ratio (HR)=4.0, 95% confidence interval (CI)=1.1-15.1) and D (HR=4.9, 95% CI=1.2-21.1) were at a significantly greater risk of pneumonia than those in Cluster A, independent of other confounding factors. Logistic regression analysis adjusting for the same covariates indicated that the number of subjects with more than 9 febrile days per year was significantly lower in Cluster A than in the other clusters. Conclusion: The comprehensive microfloral profile of the tongue coating is closely related to pneumonia-related health problems in institutionalized older adults.

Original languageEnglish
Pages (from-to)1050-1057
Number of pages8
JournalJournal of the American Geriatrics Society
Volume58
Issue number6
DOIs
Publication statusPublished - Jan 1 2010

Fingerprint

Tongue
Pneumonia
Restriction Fragment Length Polymorphisms
Health
Regression Analysis
Fever
Confidence Intervals
Nursing Homes
Longitudinal Studies
Multivariate Analysis
Retrospective Studies
Logistic Models

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology

Cite this

Microfloral characterization of the tongue coating and associated risk for pneumonia-related health problems in institutionalized older adults. / Takeshita, Toru; Tomioka, Mikiko; Shimazaki, Yoshihiro; Matsuyama, Miwa; Koyano, Kiyoshi; Matsuda, Koichi; Yamashita, Yoshihisa.

In: Journal of the American Geriatrics Society, Vol. 58, No. 6, 01.01.2010, p. 1050-1057.

Research output: Contribution to journalArticle

@article{8cac1d4e7157410caa0a172c436ced49,
title = "Microfloral characterization of the tongue coating and associated risk for pneumonia-related health problems in institutionalized older adults",
abstract = "Objectives: To characterize a comprehensive outline of the oral microflora related to pneumonia in older adults. Design: Prospective and retrospective longitudinal study. Setting: Community. Participants: Long-term hospitalized patients and people in nursing homes (343 subjects, aged ≥65). Measurements: Subjects were assessed at baseline for pneumonia-related health problems. The flora of the tongue coating was characterized according to terminal restriction fragment length polymorphism (T-RFLP) analysis. All subjects were followed prospectively for 6 months for a diagnosis of pneumonia. The number of febrile days (>37.5°C) was assessed in 299 subjects who were observed for 12 months (retrospectively for 6 months and prospectively for 6 months). The follow-up data were analyzed using multivariate regression analyses in relation to the baseline data, including T-RFLP patterns. RESUTS: T-RFLP patterns outlining the floral composition of the tongue coating were grouped into Clusters A, B, C, and D. According to Cox regression analysis, the subjects in Clusters C (hazard ratio (HR)=4.0, 95{\%} confidence interval (CI)=1.1-15.1) and D (HR=4.9, 95{\%} CI=1.2-21.1) were at a significantly greater risk of pneumonia than those in Cluster A, independent of other confounding factors. Logistic regression analysis adjusting for the same covariates indicated that the number of subjects with more than 9 febrile days per year was significantly lower in Cluster A than in the other clusters. Conclusion: The comprehensive microfloral profile of the tongue coating is closely related to pneumonia-related health problems in institutionalized older adults.",
author = "Toru Takeshita and Mikiko Tomioka and Yoshihiro Shimazaki and Miwa Matsuyama and Kiyoshi Koyano and Koichi Matsuda and Yoshihisa Yamashita",
year = "2010",
month = "1",
day = "1",
doi = "10.1111/j.1532-5415.2010.02867.x",
language = "English",
volume = "58",
pages = "1050--1057",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Microfloral characterization of the tongue coating and associated risk for pneumonia-related health problems in institutionalized older adults

AU - Takeshita, Toru

AU - Tomioka, Mikiko

AU - Shimazaki, Yoshihiro

AU - Matsuyama, Miwa

AU - Koyano, Kiyoshi

AU - Matsuda, Koichi

AU - Yamashita, Yoshihisa

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Objectives: To characterize a comprehensive outline of the oral microflora related to pneumonia in older adults. Design: Prospective and retrospective longitudinal study. Setting: Community. Participants: Long-term hospitalized patients and people in nursing homes (343 subjects, aged ≥65). Measurements: Subjects were assessed at baseline for pneumonia-related health problems. The flora of the tongue coating was characterized according to terminal restriction fragment length polymorphism (T-RFLP) analysis. All subjects were followed prospectively for 6 months for a diagnosis of pneumonia. The number of febrile days (>37.5°C) was assessed in 299 subjects who were observed for 12 months (retrospectively for 6 months and prospectively for 6 months). The follow-up data were analyzed using multivariate regression analyses in relation to the baseline data, including T-RFLP patterns. RESUTS: T-RFLP patterns outlining the floral composition of the tongue coating were grouped into Clusters A, B, C, and D. According to Cox regression analysis, the subjects in Clusters C (hazard ratio (HR)=4.0, 95% confidence interval (CI)=1.1-15.1) and D (HR=4.9, 95% CI=1.2-21.1) were at a significantly greater risk of pneumonia than those in Cluster A, independent of other confounding factors. Logistic regression analysis adjusting for the same covariates indicated that the number of subjects with more than 9 febrile days per year was significantly lower in Cluster A than in the other clusters. Conclusion: The comprehensive microfloral profile of the tongue coating is closely related to pneumonia-related health problems in institutionalized older adults.

AB - Objectives: To characterize a comprehensive outline of the oral microflora related to pneumonia in older adults. Design: Prospective and retrospective longitudinal study. Setting: Community. Participants: Long-term hospitalized patients and people in nursing homes (343 subjects, aged ≥65). Measurements: Subjects were assessed at baseline for pneumonia-related health problems. The flora of the tongue coating was characterized according to terminal restriction fragment length polymorphism (T-RFLP) analysis. All subjects were followed prospectively for 6 months for a diagnosis of pneumonia. The number of febrile days (>37.5°C) was assessed in 299 subjects who were observed for 12 months (retrospectively for 6 months and prospectively for 6 months). The follow-up data were analyzed using multivariate regression analyses in relation to the baseline data, including T-RFLP patterns. RESUTS: T-RFLP patterns outlining the floral composition of the tongue coating were grouped into Clusters A, B, C, and D. According to Cox regression analysis, the subjects in Clusters C (hazard ratio (HR)=4.0, 95% confidence interval (CI)=1.1-15.1) and D (HR=4.9, 95% CI=1.2-21.1) were at a significantly greater risk of pneumonia than those in Cluster A, independent of other confounding factors. Logistic regression analysis adjusting for the same covariates indicated that the number of subjects with more than 9 febrile days per year was significantly lower in Cluster A than in the other clusters. Conclusion: The comprehensive microfloral profile of the tongue coating is closely related to pneumonia-related health problems in institutionalized older adults.

UR - http://www.scopus.com/inward/record.url?scp=77953100430&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953100430&partnerID=8YFLogxK

U2 - 10.1111/j.1532-5415.2010.02867.x

DO - 10.1111/j.1532-5415.2010.02867.x

M3 - Article

C2 - 20487070

AN - SCOPUS:77953100430

VL - 58

SP - 1050

EP - 1057

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

IS - 6

ER -