Microfluidic autologous serum eye-drops preparation as a potential dry eye treatment

Takao Yasui, Jumpei Morikawa, Noritada Kaji, Manabu Tokeshi, Kazuo Tsubota, Yoshinobu Baba

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Dry eye is a problem in tearing quality and/or quantity and it afflicts millions of persons worldwide. An autologous serum eye-drop is a good candidate for dry eye treatment; however, the eye-drop preparation procedures take a long time and are relatively troublesome. Here we use spiral microchannels to demonstrate a strategy for the preparation of autologous serum eye-drops, which provide benefits for all dry eye patients; 100% and 90% removal efficiencies are achieved for 10 μm microbeads and whole human blood cells, respectively. Since our strategy allows researchers to integrate other functional microchannels into one device, such a microfluidic device will be able to offer a new one-step preparation system for autologous serum eye-drops.

Original languageEnglish
Article number113
JournalMicromachines
Volume7
Issue number7
DOIs
Publication statusPublished - Jul 4 2016
Externally publishedYes

Fingerprint

Microfluidics
Microchannels
Blood
Cells

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

Microfluidic autologous serum eye-drops preparation as a potential dry eye treatment. / Yasui, Takao; Morikawa, Jumpei; Kaji, Noritada; Tokeshi, Manabu; Tsubota, Kazuo; Baba, Yoshinobu.

In: Micromachines, Vol. 7, No. 7, 113, 04.07.2016.

Research output: Contribution to journalArticle

Yasui, Takao ; Morikawa, Jumpei ; Kaji, Noritada ; Tokeshi, Manabu ; Tsubota, Kazuo ; Baba, Yoshinobu. / Microfluidic autologous serum eye-drops preparation as a potential dry eye treatment. In: Micromachines. 2016 ; Vol. 7, No. 7.
@article{88ed7c2dd5084daea94806ab666f06d7,
title = "Microfluidic autologous serum eye-drops preparation as a potential dry eye treatment",
abstract = "Dry eye is a problem in tearing quality and/or quantity and it afflicts millions of persons worldwide. An autologous serum eye-drop is a good candidate for dry eye treatment; however, the eye-drop preparation procedures take a long time and are relatively troublesome. Here we use spiral microchannels to demonstrate a strategy for the preparation of autologous serum eye-drops, which provide benefits for all dry eye patients; 100{\%} and 90{\%} removal efficiencies are achieved for 10 μm microbeads and whole human blood cells, respectively. Since our strategy allows researchers to integrate other functional microchannels into one device, such a microfluidic device will be able to offer a new one-step preparation system for autologous serum eye-drops.",
author = "Takao Yasui and Jumpei Morikawa and Noritada Kaji and Manabu Tokeshi and Kazuo Tsubota and Yoshinobu Baba",
year = "2016",
month = "7",
day = "4",
doi = "10.3390/mi7070113",
language = "English",
volume = "7",
journal = "Micromachines",
issn = "2072-666X",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "7",

}

TY - JOUR

T1 - Microfluidic autologous serum eye-drops preparation as a potential dry eye treatment

AU - Yasui, Takao

AU - Morikawa, Jumpei

AU - Kaji, Noritada

AU - Tokeshi, Manabu

AU - Tsubota, Kazuo

AU - Baba, Yoshinobu

PY - 2016/7/4

Y1 - 2016/7/4

N2 - Dry eye is a problem in tearing quality and/or quantity and it afflicts millions of persons worldwide. An autologous serum eye-drop is a good candidate for dry eye treatment; however, the eye-drop preparation procedures take a long time and are relatively troublesome. Here we use spiral microchannels to demonstrate a strategy for the preparation of autologous serum eye-drops, which provide benefits for all dry eye patients; 100% and 90% removal efficiencies are achieved for 10 μm microbeads and whole human blood cells, respectively. Since our strategy allows researchers to integrate other functional microchannels into one device, such a microfluidic device will be able to offer a new one-step preparation system for autologous serum eye-drops.

AB - Dry eye is a problem in tearing quality and/or quantity and it afflicts millions of persons worldwide. An autologous serum eye-drop is a good candidate for dry eye treatment; however, the eye-drop preparation procedures take a long time and are relatively troublesome. Here we use spiral microchannels to demonstrate a strategy for the preparation of autologous serum eye-drops, which provide benefits for all dry eye patients; 100% and 90% removal efficiencies are achieved for 10 μm microbeads and whole human blood cells, respectively. Since our strategy allows researchers to integrate other functional microchannels into one device, such a microfluidic device will be able to offer a new one-step preparation system for autologous serum eye-drops.

UR - http://www.scopus.com/inward/record.url?scp=84982787012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982787012&partnerID=8YFLogxK

U2 - 10.3390/mi7070113

DO - 10.3390/mi7070113

M3 - Article

VL - 7

JO - Micromachines

JF - Micromachines

SN - 2072-666X

IS - 7

M1 - 113

ER -