Microfluidic external gelation of shape-controlled calcium-alginate hydrogels for drug encapsulation and sustained release

Yingzhe Liu, Naotomo Tottori, Takasi Nisisako

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report microfluidic in-situ external gelation for preparing calcium(Ca)-alginate hydrogels of precisely defined shapes for controlled drug release. We demonstrated that homogeneous spatial distribution of reactant CaCl2emulsions around precursor sodium(Na)-alginate droplets is essential to obtain highly spherical hydrogels. UV-Vis measurement was performed to demonstrate sustained release of encapsulated anti-fouling drug Irgarol. Magneto-responsive Janus gels and hemi-spherical gels made from Na-alginate/Grycerol Janus droplets are also presented.

Original languageEnglish
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages2183-2184
Number of pages2
ISBN (Electronic)9781510897571
Publication statusPublished - Jan 1 2018
Externally publishedYes
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
Duration: Nov 11 2018Nov 15 2018

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume4

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period11/11/1811/15/18

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

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  • Cite this

    Liu, Y., Tottori, N., & Nisisako, T. (2018). Microfluidic external gelation of shape-controlled calcium-alginate hydrogels for drug encapsulation and sustained release. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 (pp. 2183-2184). (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018; Vol. 4). Chemical and Biological Microsystems Society.