MICROFLUIDIC METHODOLOGIES FOR PRODUCTION OF SMALL-SIZED VARIOUS ARTIFICIAL EXOSOMES

Niko Kimura, Takuma Nomiyama, Toyohiro Naito, Masatoshi Maeki, Manabu Tokeshi, Noritada Kaji

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper describes microfluidic methodologies for production of sub-100 nm sized various types of artificial exosomes by separately injecting of phospholipids dissolved ethanol solution. The separated injection method allowed production of smaller-sized artificial exosomes with high encapsulation efficiency of small interfering RNA (siRNA) regardless of natural exosome-like lipid systems than the conventional combined injection method. The prepared artificial exosomes were taken into cells depending on the average sizes, lipid systems, and cell types. This microfluidic method is expected to contribute to exosomal research and development of exosomal nanomedicines.

Original languageEnglish
Title of host publicationMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages355-356
Number of pages2
ISBN (Electronic)9781733419031
Publication statusPublished - 2021
Event25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 - Palm Springs, Virtual, United States
Duration: Oct 10 2021Oct 14 2021

Publication series

NameMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Country/TerritoryUnited States
CityPalm Springs, Virtual
Period10/10/2110/14/21

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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