Microfluidic single-particle chemical analyzer with dual-comb coherent Raman spectroscopy

Takuro Ideguchi; Tasuku Nakamura; Shigekazu Takizawa; Miu Tamamitsu; Sangwook Lee; Kotaro Hiramatsu; Venkata Ramaiah-Badarla; Jee Woong Park; Yusuke Kasai; Takeshi Hayakawa; Shinya Sakuma; Fumihito Arai; Keisuke Goda

doi:10.1364/OL.43.004057

Microfluidic single-particle chemical analyzer with dual-comb coherent Raman spectroscopy

Takuro Ideguchi, Tasuku Nakamura, Shigekazu Takizawa, Miu Tamamitsu, Sangwook Lee, Kotaro Hiramatsu, Venkata Ramaiah-Badarla, Jee Woong Park, Yusuke Kasai, Takeshi Hayakawa, Shinya Sakuma, Fumihito Arai, Keisuke Goda

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Label-free particle analysis is a powerful tool in chemical, pharmaceutical, and cosmetic industries as well as in basic sciences, but its throughput is significantly lower than that of fluorescence-based counterparts. Here we present a labelfree single-particle analyzer based on broadband dual-comb coherent Raman scattering spectroscopy operating at a spectroscopic scan rate of 10 kHz. As a proof-of-concept demonstration, we perform broadband coherent anti-Stokes Raman scattering measurements of polystyrene microparticles flowing on an acoustofluidic chip at a high throughput of >1000 particles per second. This high-throughput labelfree particle analyzer has the potential for high-precision statistical analysis of a large number of microparticles including biological cells.

Original language	English
Pages (from-to)	4057-4060
Number of pages	4
Journal	Optics Letters
Volume	43
Issue number	16
DOIs	https://doi.org/10.1364/OL.43.004057
Publication status	Published - Aug 15 2018
Externally published	Yes

All Science Journal Classification (ASJC) codes

Atomic and Molecular Physics, and Optics

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10.1364/OL.43.004057

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title = "Microfluidic single-particle chemical analyzer with dual-comb coherent Raman spectroscopy",

abstract = "Label-free particle analysis is a powerful tool in chemical, pharmaceutical, and cosmetic industries as well as in basic sciences, but its throughput is significantly lower than that of fluorescence-based counterparts. Here we present a labelfree single-particle analyzer based on broadband dual-comb coherent Raman scattering spectroscopy operating at a spectroscopic scan rate of 10 kHz. As a proof-of-concept demonstration, we perform broadband coherent anti-Stokes Raman scattering measurements of polystyrene microparticles flowing on an acoustofluidic chip at a high throughput of >1000 particles per second. This high-throughput labelfree particle analyzer has the potential for high-precision statistical analysis of a large number of microparticles including biological cells.",

author = "Takuro Ideguchi and Tasuku Nakamura and Shigekazu Takizawa and Miu Tamamitsu and Sangwook Lee and Kotaro Hiramatsu and Venkata Ramaiah-Badarla and Park, {Jee Woong} and Yusuke Kasai and Takeshi Hayakawa and Shinya Sakuma and Fumihito Arai and Keisuke Goda",

note = "Funding Information: Funding. ImPACT Program of the Council for Science, Technology and Innovation; Cabinet Office, Government of Japan. Publisher Copyright: {\textcopyright} 2018 Optical Society of America.",

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doi = "10.1364/OL.43.004057",

language = "English",

volume = "43",

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journal = "Optics Letters",

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AU - Ideguchi, Takuro

AU - Nakamura, Tasuku

AU - Takizawa, Shigekazu

AU - Tamamitsu, Miu

AU - Lee, Sangwook

AU - Hiramatsu, Kotaro

AU - Ramaiah-Badarla, Venkata

AU - Park, Jee Woong

AU - Kasai, Yusuke

AU - Hayakawa, Takeshi

AU - Sakuma, Shinya

AU - Arai, Fumihito

AU - Goda, Keisuke

PY - 2018/8/15

Y1 - 2018/8/15

N2 - Label-free particle analysis is a powerful tool in chemical, pharmaceutical, and cosmetic industries as well as in basic sciences, but its throughput is significantly lower than that of fluorescence-based counterparts. Here we present a labelfree single-particle analyzer based on broadband dual-comb coherent Raman scattering spectroscopy operating at a spectroscopic scan rate of 10 kHz. As a proof-of-concept demonstration, we perform broadband coherent anti-Stokes Raman scattering measurements of polystyrene microparticles flowing on an acoustofluidic chip at a high throughput of >1000 particles per second. This high-throughput labelfree particle analyzer has the potential for high-precision statistical analysis of a large number of microparticles including biological cells.

AB - Label-free particle analysis is a powerful tool in chemical, pharmaceutical, and cosmetic industries as well as in basic sciences, but its throughput is significantly lower than that of fluorescence-based counterparts. Here we present a labelfree single-particle analyzer based on broadband dual-comb coherent Raman scattering spectroscopy operating at a spectroscopic scan rate of 10 kHz. As a proof-of-concept demonstration, we perform broadband coherent anti-Stokes Raman scattering measurements of polystyrene microparticles flowing on an acoustofluidic chip at a high throughput of >1000 particles per second. This high-throughput labelfree particle analyzer has the potential for high-precision statistical analysis of a large number of microparticles including biological cells.

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Microfluidic single-particle chemical analyzer with dual-comb coherent Raman spectroscopy

Abstract

All Science Journal Classification (ASJC) codes

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