Microglia and intractable chronic pain

Makoto Tsuda, Simon Beggs, Michael W. Salter, Kazuhide Inoue

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Many pathological processes within the central nervous system are mediated by complex interactions between neurons and resident glial cells. In the case of painful peripheral neuropathy, spinal microglia react and undergo a series of changes that directly influence the establishment of neuropathic pain states. Purinergic signaling has been shown to be at the center of this reactivity, and here we review recent mechanistic advances describing the importance of microglial P2 receptors and their interactions with neuronal populations in the development of neuropathic pain.

Original languageEnglish
Pages (from-to)55-61
Number of pages7
JournalGLIA
Volume61
Issue number1
DOIs
Publication statusPublished - Jan 1 2013

Fingerprint

Intractable Pain
Microglia
Neuralgia
Chronic Pain
Peripheral Nervous System Diseases
Pathologic Processes
Neuroglia
Central Nervous System
Neurons
Population
Painful Neuropathy

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cellular and Molecular Neuroscience

Cite this

Microglia and intractable chronic pain. / Tsuda, Makoto; Beggs, Simon; Salter, Michael W.; Inoue, Kazuhide.

In: GLIA, Vol. 61, No. 1, 01.01.2013, p. 55-61.

Research output: Contribution to journalArticle

Tsuda, Makoto ; Beggs, Simon ; Salter, Michael W. ; Inoue, Kazuhide. / Microglia and intractable chronic pain. In: GLIA. 2013 ; Vol. 61, No. 1. pp. 55-61.
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