Microglia in the CNS and neuropathic pain

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Neuropathic pain occurring after peripheral nerve injury is not simply a consequence of temporal continuity of acute nociceptive signals, but rather of maladaptive nervous system function. Over the past decades, a body of literature has provided evidence for the necessity and sufficiency of microglia, the tissue-resident macrophages of the central nervous system, for nerve injury-induced alterations in synaptic function. Recent studies have also revealed active roles for microglia in brain regions important for emotion and memory. In this chapter, I highlight recent advances in our understanding of the mechanisms that underlie the role of spinal and brain microglia in neuropathic pain, with a focus on how microglia are activated and alter synaptic function. I also discuss the therapeutic potential of microglia from recent advances in the development of new drugs targeting microglia, which may facilitate translation from the bench to bedside.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages77-91
Number of pages15
DOIs
Publication statusPublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1099
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

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Microglia
Neuralgia
Neurology
Brain
Nervous System Trauma
Peripheral Nerve Injuries
Macrophages
Drug Delivery Systems
Nervous System
Emotions
Central Nervous System
Tissue
Data storage equipment

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Makoto, T. (2018). Microglia in the CNS and neuropathic pain. In Advances in Experimental Medicine and Biology (pp. 77-91). (Advances in Experimental Medicine and Biology; Vol. 1099). Springer New York LLC. https://doi.org/10.1007/978-981-13-1756-9_7

Microglia in the CNS and neuropathic pain. / Makoto, Tsuda.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. p. 77-91 (Advances in Experimental Medicine and Biology; Vol. 1099).

Research output: Chapter in Book/Report/Conference proceedingChapter

Makoto, T 2018, Microglia in the CNS and neuropathic pain. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1099, Springer New York LLC, pp. 77-91. https://doi.org/10.1007/978-981-13-1756-9_7
Makoto T. Microglia in the CNS and neuropathic pain. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2018. p. 77-91. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-981-13-1756-9_7
Makoto, Tsuda. / Microglia in the CNS and neuropathic pain. Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. pp. 77-91 (Advances in Experimental Medicine and Biology).
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