Microglial regulation of neuropathic pain

Research output: Contribution to journalReview article

77 Citations (Scopus)

Abstract

Neuropathic pain is a highly debilitating chronic pain state that is a consequence of nerve injury or of diseases such as diabetes, cancer, infection, autoimmune disease, or trauma. Neuropathic pain is often resistant to currently available analgesics. There is a rapidly growing body of evidence indicating that signalings from spinal microglia play crucial roles in the pathogenesis of neuropathic pain. After peripheral nerve injury, microglia transform to reactive states through the expression of various genes such as cell-surface receptors (including purinergic receptors) and proinflammatory cytokines that enhance synaptic transmission in dorsal horn neurons. Inhibiting function or expression of these microglial molecules strongly suppresses pain hypersensitivity to innocuous mechanical stimuli (tactile allodynia), a hallmark symptom of neuropathic pain. A recent study also reveals that the transcription factor IRF8 (interferon regulatory factor 8) is a critical regulator of the nerve injury-induced gene expression in microglia. The present review article highlights the recent advances in our understanding of spinal microglia in neuropathic pain.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalJournal of Pharmacological Sciences
Volume121
Issue number2
DOIs
Publication statusPublished - Feb 26 2013

Fingerprint

Neuralgia
Microglia
Wounds and Injuries
Posterior Horn Cells
Gene Expression
Purinergic Receptors
Peripheral Nerve Injuries
Hyperalgesia
Cell Surface Receptors
Synaptic Transmission
Chronic Pain
Autoimmune Diseases
Analgesics
Hypersensitivity
Transcription Factors
Cytokines
Pain
Infection
Neoplasms

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Microglial regulation of neuropathic pain. / Tsuda, Makoto; Masuda, Takahiro; Tozaki-Saitoh, Hidetoshi; Inoue, Kazuhide.

In: Journal of Pharmacological Sciences, Vol. 121, No. 2, 26.02.2013, p. 89-94.

Research output: Contribution to journalReview article

@article{43c87e6567e4432293a27a0d1a015a7b,
title = "Microglial regulation of neuropathic pain",
abstract = "Neuropathic pain is a highly debilitating chronic pain state that is a consequence of nerve injury or of diseases such as diabetes, cancer, infection, autoimmune disease, or trauma. Neuropathic pain is often resistant to currently available analgesics. There is a rapidly growing body of evidence indicating that signalings from spinal microglia play crucial roles in the pathogenesis of neuropathic pain. After peripheral nerve injury, microglia transform to reactive states through the expression of various genes such as cell-surface receptors (including purinergic receptors) and proinflammatory cytokines that enhance synaptic transmission in dorsal horn neurons. Inhibiting function or expression of these microglial molecules strongly suppresses pain hypersensitivity to innocuous mechanical stimuli (tactile allodynia), a hallmark symptom of neuropathic pain. A recent study also reveals that the transcription factor IRF8 (interferon regulatory factor 8) is a critical regulator of the nerve injury-induced gene expression in microglia. The present review article highlights the recent advances in our understanding of spinal microglia in neuropathic pain.",
author = "Makoto Tsuda and Takahiro Masuda and Hidetoshi Tozaki-Saitoh and Kazuhide Inoue",
year = "2013",
month = "2",
day = "26",
doi = "10.1254/jphs.12R14CP",
language = "English",
volume = "121",
pages = "89--94",
journal = "Journal of Pharmacological Sciences",
issn = "1347-8613",
publisher = "Japanese Pharmacological Society",
number = "2",

}

TY - JOUR

T1 - Microglial regulation of neuropathic pain

AU - Tsuda, Makoto

AU - Masuda, Takahiro

AU - Tozaki-Saitoh, Hidetoshi

AU - Inoue, Kazuhide

PY - 2013/2/26

Y1 - 2013/2/26

N2 - Neuropathic pain is a highly debilitating chronic pain state that is a consequence of nerve injury or of diseases such as diabetes, cancer, infection, autoimmune disease, or trauma. Neuropathic pain is often resistant to currently available analgesics. There is a rapidly growing body of evidence indicating that signalings from spinal microglia play crucial roles in the pathogenesis of neuropathic pain. After peripheral nerve injury, microglia transform to reactive states through the expression of various genes such as cell-surface receptors (including purinergic receptors) and proinflammatory cytokines that enhance synaptic transmission in dorsal horn neurons. Inhibiting function or expression of these microglial molecules strongly suppresses pain hypersensitivity to innocuous mechanical stimuli (tactile allodynia), a hallmark symptom of neuropathic pain. A recent study also reveals that the transcription factor IRF8 (interferon regulatory factor 8) is a critical regulator of the nerve injury-induced gene expression in microglia. The present review article highlights the recent advances in our understanding of spinal microglia in neuropathic pain.

AB - Neuropathic pain is a highly debilitating chronic pain state that is a consequence of nerve injury or of diseases such as diabetes, cancer, infection, autoimmune disease, or trauma. Neuropathic pain is often resistant to currently available analgesics. There is a rapidly growing body of evidence indicating that signalings from spinal microglia play crucial roles in the pathogenesis of neuropathic pain. After peripheral nerve injury, microglia transform to reactive states through the expression of various genes such as cell-surface receptors (including purinergic receptors) and proinflammatory cytokines that enhance synaptic transmission in dorsal horn neurons. Inhibiting function or expression of these microglial molecules strongly suppresses pain hypersensitivity to innocuous mechanical stimuli (tactile allodynia), a hallmark symptom of neuropathic pain. A recent study also reveals that the transcription factor IRF8 (interferon regulatory factor 8) is a critical regulator of the nerve injury-induced gene expression in microglia. The present review article highlights the recent advances in our understanding of spinal microglia in neuropathic pain.

UR - http://www.scopus.com/inward/record.url?scp=84874130784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874130784&partnerID=8YFLogxK

U2 - 10.1254/jphs.12R14CP

DO - 10.1254/jphs.12R14CP

M3 - Review article

C2 - 23337437

AN - SCOPUS:84874130784

VL - 121

SP - 89

EP - 94

JO - Journal of Pharmacological Sciences

JF - Journal of Pharmacological Sciences

SN - 1347-8613

IS - 2

ER -