Abstract
The immobilization and the micro-patterning of biomolecules on the solid surfaces are paid much attention for the application of biomaterials, and biosensors. Micro-patterned carbohydrates on solid surfaces are useful to analyze carbohydrate-protein interactions and to fabricate the scaffolds of cell cultivation. We have proposed a new method for micro-patterned carbohydrate display. The micropattern composed of hydrophobic and electrostatically positive regions were fabricated by methyl and amino terminated self-assembled monolayers (SAM). The patterned substrates were incubated in two types of aqueous solutions of PVLA and Heparin, in this order. The PVLA and Heparin site-selectively adsorbed on methyl and amino terminated SAMs, respectively. It indicated that the two dimensional matrix of PVLA and Heparin can be fabricated on the micro-patterned substrate. The micropatterning of two different components on one substrate enables two different biomacromolecules to be self-assembled into micro pattern.
Original language | English |
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Number of pages | 1 |
Publication status | Published - Dec 1 2005 |
Externally published | Yes |
Event | 54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: May 25 2005 → May 27 2005 |
Other
Other | 54th SPSJ Annual Meeting 2005 |
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Country | Japan |
City | Yokohama |
Period | 5/25/05 → 5/27/05 |
All Science Journal Classification (ASJC) codes
- Engineering(all)