Micropatterning electrospun scaffolds to create intrinsic vascular networks

Eric M. Jeffries, Shintaro Nakamura, Kee Won Lee, Jimmy Clampffer, Hiroyuki Ijima, Yadong Wang

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Sufficient vascularization is critical to sustaining viable tissue-engineered (TE) constructs after implantation. Despite significant progress, current approaches lack suturability, porosity, and biodegradability, which hinders rapid perfusion and remodeling in vivo. Consequently, TE vascular networks capable of direct anastomosis to host vasculature and immediate perfusion upon implantation still remain elusive. Here, a hybrid fabrication method is presented for micropatterning fibrous scaffolds that are suturable, porous, and biodegradable. Fused deposition modeling offers an inexpensive and automated approach to creating sacrificial templates with vascular-like branching. By electrospinning around these poly(vinyl alcohol) templates and dissolving them in water, microvascular patterns were transferred to fibrous scaffolds. Results indicated that these scaffolds have sufficient suture retention strength to permit direct anastomosis in future studies. Vascularization of these scaffolds is demonstrated by in vitro endothelialization and perfusion.

Original languageEnglish
Pages (from-to)1514-1520
Number of pages7
JournalMacromolecular Bioscience
Volume14
Issue number11
DOIs
Publication statusPublished - Nov 1 2014

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Micropatterning electrospun scaffolds to create intrinsic vascular networks'. Together they form a unique fingerprint.

Cite this