microRNA-181a is associated with poor prognosis of colorectal cancer

Junichi Nishimura, Rio Handa, Hirofumi Yamamoto, Fumiaki Tanaka, Kohei Shibata, Koshi Mimori, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Mitsugu Sekimoto, Hideshi Ishii, Yuichiro Doki, Masaki Mori

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

MiRNAs regulate gene expression at the post-transcriptional level by degradation of mRNA and translational repression. Recent studies have shown that miR-181a is dysregulated in several types of cancer; however, the clinical significance of miR-181a in colorectal cancer (CRC) remains unclear. We addressed this question by using quantitative real-time PCR (qRT-PCR) to analyze miR-181a expression in 162 CRC patients. There was no significant difference in miR-181a expression in normal colon vs. colorectal cancer tissue. The cancer tissue samples were categorized into a low and high expression group based on miR-181a expression. Comparison of the clinicopathological factors and prognosis in these two groups showed t hat the high expression group had a signi fica ntly poorer prognosis than the low expression group (P= 0.011). Multiva riate analysis indicated that high miR-181a expression was an independent significant prognostic factor for CRC. However, there no correlation was observed between miR-181a expression and clinicopathological parameters. In vitro analysis revealed that the overexpression of miR-181a repressed the expression of the tumor suppressor, phosphatase and tensin homolog (PTEN) located on chromosome 10, at the mRNA level. These data suggest that miR-181a may be a new independent prognostic factor for CRC patients.

Original languageEnglish
Pages (from-to)2221-2226
Number of pages6
JournalOncology reports
Volume28
Issue number6
DOIs
Publication statusPublished - Dec 2012

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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